Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.

Nat Genet 2012 Oct 2;44(10):1147-51. Epub 2012 Sep 2.

Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.

Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR)=1.62, P=3.9×10(-8)) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR=1.15, P=3.9×10(-4); discovery and replication combined OR=1.21, P=4.7×10(-8)). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke.

Download full-text PDF

Source
http://www.nature.com/articles/ng.2397
Publisher Site
http://dx.doi.org/10.1038/ng.2397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651583PMC
October 2012
32 Reads

Publication Analysis

Top Keywords

ischemic stroke
24
genetic risk
12
population controls
8
laa cases
8
large artery
8
stroke
7
ischemic
6
laa
6
population cohorts
4
cases 1244
4
independent population
4
52695 population
4
controls australia
4
controls independent
4
1244 population
4
including 421
4
meta-analysis replication
4
atherosclerosis laa
4
artery atherosclerosis
4
replication or=115
4

Similar Publications