Photodynamic therapy of condyloma acuminata in pregnant women.

Chin Med J (Engl) 2012 Aug;125(16):2925-8

Department of Dermatology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.

Background: Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an emerging technique for the treatment of genital human papillomavirus (HPV)-induced benign and premalignant lesions. We report here in a case series of condyloma acuminata (CA) in pregnancy successfully treated with ALA-PDT.

Methods: Five pregnant patients with CA received three to four times treatment respectively. Patients were followed up for 6 - 23 months after treatment.

Results: The clearance rate of genital warts was 100%. No recurrence was found during the follow-up period. Major adverse events reported were mild erosion, pain, and local edema. All pregnancies resulted in healthy live births without delivery complications.

Conclusions: PDT with topical ALA seems to be safe and effective in the treatment of CA in pregnancy. It demonstrated high clearance rate of warts, was well-tolerated by patients, and showed no adverse effects on mothers or fetuses. ALA-PDT may be an ideal strategy of treatment for pregnant women with CA.

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August 2012
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