Children's urinary phthalate metabolites and fractional exhaled nitric oxide in an urban cohort.

Authors:
Adnan Divjan
Adnan Divjan
Mailman School of Public Health, Columbia University
Officer of Research
Asthma__General, Asthma__Child / Adolescent, Asthma__Environmental Triggers, Asthma, Asthma, Environmental Risk Factors,Minority Health Issues__Asthma
New York, NY | United States

Am J Respir Crit Care Med 2012 Nov 23;186(9):830-7. Epub 2012 Aug 23.

Columbia Center for Children’s Environmental Health, Mailman School of Public Health, Columbia University, 722 W. 168th Street, New York, NY 10032, USA.

Rationale: Phthalates are used widely in consumer products. Exposure to several phthalates has been associated with respiratory symptoms and decreased lung function. Associations between children's phthalate exposures and fractional exhaled nitric oxide (Fe(NO)), a biomarker of airway inflammation, have not been examined.

Objectives: We hypothesized that urinary concentrations of four phthalate metabolites would be positively associated with Fe(NO) and that these associations would be stronger among children with seroatopy or wheeze.

Methods: In an urban ongoing birth cohort, 244 children had phthalate metabolites determined in urine collected on the same day as Fe(NO) measurement. Repeated sampling gathered 313 observations between ages 4.9 and 9.1 years. Seroatopy was assessed by specific IgE. Wheeze in the past year was assessed by validated questionnaire. Regression models used generalized estimating equations.

Measurements And Main Results: Log-unit increases in urinary concentrations of metabolites of diethyl phthalate (DEP) and butylbenzyl phthalate (BBzP) were associated with a 6.6% (95% confidence interval [CI] 0.5-13.1%) and 8.7% (95% CI, 1.9-16.0%) increase in Fe(NO), respectively, adjusting for other phthalate metabolites and potential covariates/confounders. There was no association between concentrations of metabolites of di(2-ethylhexyl) phthalate or di-n-butyl phthalate and Fe(NO). There was no significant interaction by seroatopy. The BBzP metabolite association was significantly stronger among children who wheeze (P = 0.016).

Conclusions: Independent associations between exposures to DEP and BBzP and Fe(NO) in a cohort of inner-city children were observed. These results suggest that these two ubiquitous phthalates, previously shown to have substantial contributions from inhalation, are positively associated with airway inflammation in children.

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Source
http://dx.doi.org/10.1164/rccm.201203-0398OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530221PMC
November 2012
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References

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Adibi JJ et al.
Environ Health Perspect 2008

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