A genome-wide association study of breast cancer in women of African ancestry.

Hum Genet 2013 Jan 25;132(1):39-48. Epub 2012 Aug 25.

Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Genome-wide association studies (GWAS) in diverse populations are needed to reveal variants that are more common and/or limited to defined populations. We conducted a GWAS of breast cancer in women of African ancestry, with genotyping of >1,000,000 SNPs in 3,153 African American cases and 2,831 controls, and replication testing of the top 66 associations in an additional 3,607 breast cancer cases and 11,330 controls of African ancestry. Two of the 66 SNPs replicated (p < 0.05) in stage 2, which reached statistical significance levels of 10(-6) and 10(-5) in the stage 1 and 2 combined analysis (rs4322600 at chromosome 14q31: OR = 1.18, p = 4.3 × 10(-6); rs10510333 at chromosome 3p26: OR = 1.15, p = 1.5 × 10(-5)). These suggestive risk loci have not been identified in previous GWAS in other populations and will need to be examined in additional samples. Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00439-012-1214-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749077PMC
January 2013
17 Reads
40 Citations
4.824 Impact Factor

Publication Analysis

Top Keywords

breast cancer
16
african ancestry
16
women african
12
cancer women
12
genome-wide association
8
african
5
samples identification
4
snps replicated
4
11330 controls
4
controls african
4
ancestry snps
4
replicated 005
4
reached statistical
4
statistical significance
4
additional samples
4
stage reached
4
005 stage
4
cases 11330
4
identification novel
4
risk variants
4

References

(Supplied by CrossRef)

S Ahmed et al.
Nat Genet 2009

AC Antoniou et al.
Nat Genet 2010

MC Campbell et al.
Annu Rev Genomics Hum Genet 2008

F Chen et al.
Eur J Hum Genet 2010

F Chen et al.
Hum Mol Genet 2011

DF Easton et al.
Nature 2007

O Fletcher et al.
J Natl Cancer Inst 2011

M Ghoussaini et al.
Nat Genet 2012

CA Haiman et al.
Nat Genet 2011

CA Haiman et al.
Nat Genet 2011

DJ Hunter et al.
Nat Genet 2007

Similar Publications