Dietary cholesterol increases paraoxonase 1 enzyme activity.

J Lipid Res 2012 Nov 15;53(11):2450-8. Epub 2012 Aug 15.

Department of Medicine and University of Washington School of Medicine, Seattle, WA, USA.

HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk (CLEAR) cohort. The goal of this study was to replicate these findings and determine whether other nutrient intake affected PON1 activity. To predict nutrient and mineral intake values, 1,402 subjects completed a standardized food frequency survey of their dietary habits over the past year. Stepwise regression was used to evaluate dietary and covariate effects on PON1 arylesterase activity. Five dietary components, cholesterol (P < 2.0 × 10(-16)), alcohol (P = 8.51 × 10(-8)), vitamin C (P = 7.97 × 10(-5)), iron (P = 0.0026), and folic acid (0.037) were independently predictive of PON1 activity. Dietary cholesterol was positively associated and predicted 5.5% of PON1 activity, second in variance explained. This study presents a novel finding of dietary cholesterol, iron, and folic acid predicting PON1 activity in humans and confirms prior reported associations, including that with vitamin C. Identifying and understanding environmental factors that affect PON1 activity is necessary to understand its role and that of HDL in human disease.

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.P030601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466014PMC
November 2012
18 Reads

Publication Analysis

Top Keywords

pon1 activity
24
dietary cholesterol
12
activity
8
positively associated
8
pon1
8
folic acid
8
activity dietary
8
dietary
6
vitamin 797
4
10-16 alcohol
4
10-8 vitamin
4
851 10-8
4
alcohol 851
4
10-5 iron
4
0037 independently
4
independently predictive
4
predictive pon1
4
acid 0037
4
00026 folic
4
cholesterol 10-16
4

References

(Supplied by CrossRef)

Similar Publications