Plasma MicroRNA-21 concentration may be a useful biomarker in glioblastoma patients.

Authors:
Ludwig Wagner
Ludwig Wagner
University Clinic for Internal Medicine III General Hospital Vienna
Julia Furtner
Julia Furtner
Medical University of Vienna
Georg Widhalm
Georg Widhalm
Medical University of Vienna
Christine Marosi
Christine Marosi
Medical University of Vienna
Austria
Matthias Preusser
Matthias Preusser
Medical University of Vienna
Wien | Austria

Cancer Invest 2012 Oct 14;30(8):615-21. Epub 2012 Aug 14.

Department of Medicine, Comprehensive Cancer Center-Central Nervous System Tumours Unit (CCC-CNS), Medical University of Vienna, Vienna, Austria.

Background: MicroRNAs are proposed as plasma biomarkers in cancer. Glioblastoma is the most frequent primary brain tumor of adults. MicroRNA-21 was shown to induce glioblastoma growth.

Aims: To evaluate the circulating microRNA-21 in glioblastoma patients.

Methods: MicroRNA-21 copies in glioblastoma plasma (n = 10, before surgery and during/after concomitant chemoradiotherapy), control plasma (n = 10), and tissue samples were analyzed using RT-qPCR.

Results: MicroRNA-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). One patient with increasing microRNA-21 developed a histopathologically proven recurrence after the second sample collection.

Discussion: Circulating microRNA-21 might be a useful biomarker in glioblastoma.

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Source
http://www.tandfonline.com/doi/full/10.3109/07357907.2012.70
Publisher Site
http://dx.doi.org/10.3109/07357907.2012.708071DOI Listing
October 2012
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