J Alzheimers Dis 2013 ;33(1):3-16
Department of Biology, Drexel University, Philadelphia, PA 19104, USA.
Cereb Cortex 2021 Mar 2. Epub 2021 Mar 2.
cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität, 80337 Munich, Germany.
Younger age at first exposure (AFE) to repetitive head impacts while playing American football increases the risk for later-life neuropsychological symptoms and brain alterations. However, it is not known whether AFE is associated with cortical thickness in American football players. Sixty-three former professional National Football League players (55. Read More
Bioorg Med Chem 2021 Feb 27;36:116091. Epub 2021 Feb 27.
Department of Medicinal Chemistry, B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India. Electronic address:
Alzheimer's disease (AD) is a neurodegenerative disease majorly affecting old age populations. Various factors that affect the progression of the disease include, amyloid plaque formation, neurofibrillary tangles, inflammation, oxidative stress, etc. Herein we report of a new series of substituted (2-aminothiazol-5-yl)(imidazo[1,2-a]pyridin-3-yl)methanones. Read More
Toxicol Lett 2021 Mar 3. Epub 2021 Mar 3.
School of Medicine, Sun Yat-Sen University, Guangzhou, 518000, China; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, China; International Joint Laboratoryof Novel Anti-Dementia Drugs of Guangzhou, Guangzhou, China. Electronic address:
Acrolein is a universal contaminant with high nucleophilicity in environment and also an endogenous product from lipid peroxidation or polyamine metabolism. Acrolein can react with nucleophilic amino acids, such as cysteines, lysines and histidines via Michael addition. Also, Schiff base products can be formed between acrolein and free amine of lysines. Read More
Exp Gerontol 2021 Mar 3:111303. Epub 2021 Mar 3.
Department of Gerontology, Federal University of São Carlos (UFSCar), Rod. Washignton Luis, Km 235, Monjolinho, São Carlos, SP 13565-905, Brazil.
Mild cognitive impairment (MCI) associated with physical frailty gave rise to the new concept of cognitive frailty. Previous studies have suggested that MCI may represent a condition that precedes Alzheimer's disease (AD), in view of its higher conversion rate to dementia, when compared with the conversion rate of cognitively healthy older adults. Therefore, and considering that MCI represents a reversible condition, the identification of biomarkers for this condition is imperative to early diagnosis. Read More
Neurosci Biobehav Rev 2021 Mar 3. Epub 2021 Mar 3.
Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; APC Microbiome Institute, University College Cork, Cork, Ireland. Electronic address:
There is increasing knowledge regarding the role of the microbiome in modulating brain and behaviour. Indeed, the actions of microbial metabolites are key for appropriate gut-brain communication in humans. Among these metabolites short-chain fatty acids, tryptophan, and bile acid metabolites/pathways show strong preclinical evidence for involvement in various aspects of brain function and behaviour. Read More