Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion.

J Pediatr 2012 Oct 27;161(4):760-2. Epub 2012 Jul 27.

Department of Pediatrics, Division of Pediatric Endocrinology, Oregon Health & Science University Doernbecher Children's Hospital, Portland, OR 972389, USA.

We report the cases of 3 infants with congenital hypothyroidism detected with the use of our newborn screening program, with evidence supporting excess maternal iodine ingestion (12.5 mg/d) as the etiology. Levels of whole blood iodine extracted from their newborn screening specimens were 10 times above mean control levels. Excess iodine ingestion from nutritional supplements is often unrecognized.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2012.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354797PMC
October 2012
5 Reads

Publication Analysis

Top Keywords

iodine ingestion
8
newborn screening
8
congenital hypothyroidism
8
ingestion 125
4
125 mg/d
4
etiology levels
4
mg/d etiology
4
maternal iodine
4
screening program
4
program evidence
4
evidence supporting
4
supporting excess
4
levels blood
4
iodine extracted
4
excess iodine
4
ingestion nutritional
4
nutritional supplements
4
supplements unrecognized
4
levels excess
4
control levels
4

Similar Publications