Evaluation of periimplant crevicular fluid prostaglandin E2 and matrix metalloproteinase-8 levels from health to periimplant disease status: a prospective study.

Implant Dent 2012 Aug;21(4):306-10

Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Turkey.

Objective: To compare the levels of prostaglandin E2 (PGE2) and matrix metalloproteinases-8 (MMP-8) in periimplant crevicular fluid (PICF) after osseointegration and loading.

Materials And Methods: PICF was collected at the 3rd, 6th, 12th, and 18th months after implantation of 72 implants. PGE2 and MMP-8 levels besides clinical parameters were evaluated.

Results: Plaque and gingival index at the 6th, 12th, and 18th months presented higher values. Probing depth showed an increase after the 12th month. PGE2 presented a higher value at the 18th month. MMP-8 level demonstrated higher values after the sixth month. PGE2 and MMP-8 demonstrated positive correlations with gingival index and probing depth.

Conclusion: The detection of PGE2 and MMP-8 in PICF serve to be useful for monitoring the course of periimplant disease. MMP-8 promises to be an early signal of periimplant inflammation.

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http://dx.doi.org/10.1097/ID.0b013e3182588408DOI Listing
August 2012
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