The Drosophila female aphrodisiac pheromone activates ppk23(+) sensory neurons to elicit male courtship behavior.

Authors:
Hirofumi Toda
Hirofumi Toda
Kinki University Hospital.
Dr. XiaoLiang Zhao, PhD
Dr. XiaoLiang Zhao, PhD
Janelia Research Campus, HHMI
Research Specialist
Neurobiology
Ashburn, VIRGINIA | United States
Barry J Dickson
Barry J Dickson
Research Institute of Molecular Pathology
Austria

Cell Rep 2012 Jun 24;1(6):599-607. Epub 2012 May 24.

Research Institute of Molecular Pathology, Dr. Bohrgasse 7, A-1030 Vienna, Austria.

Females of many animal species emit chemical signals that attract and arouse males for mating. For example, the major aphrodisiac pheromone of Drosophila melanogaster females, 7,11-heptacosadiene (7,11-HD), is a potent inducer of male-specific courtship and copulatory behaviors. Here, we demonstrate that a set of gustatory sensory neurons on the male foreleg, defined by expression of the ppk23 marker, respond to 7,11-HD. Activity of these neurons is required for males to robustly court females or to court males perfumed with 7,11-HD. Artificial activation of these ppk23(+) neurons stimulates male-male courtship even without 7,11-HD perfuming. These data identify the ppk23(+) sensory neurons as the primary targets for female sex pheromones in Drosophila.

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http://dx.doi.org/10.1016/j.celrep.2012.05.007DOI Listing
June 2012
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