G Ital Dermatol Venereol 1990 Jun;125(6):281-4
Divisione di Dermatologia, E.O. Ospedali Galliera, Genova.
Med Cutan Ibero Lat Am 1989 ;17(5):321-5
Hospital Universitario de Valladolid.
The case of a female patient, 67 years old, with hyperkeratotic papules in the lower extremities which are characteristic of hyperkeratosis lenticularis perstans is reported. The clinical, histological and ultrastructural findings are shown. We have recorded the absence of Odland bodies in the area of the lesion, the persistence of desmosomes in the stratum corneum and lymphocytes with cerebriform nuclei within the inflammatory cell infiltrate. Read More
Am J Dermatopathol 2006 Apr;28(2):122-6
Department of Dermatology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
A case of hyperkeratosis lenticularis perstans (Flegel's disease) was studied histopathologically comparing early and old lesions. The age of the lesions were judged by both the patient's history and direct observation. The histopathologic and immunophenotypic features of a new lesion were essentially in accordance with previous findings. Read More
J Am Acad Dermatol 2016 Dec;75(6):e211-e213
Guangdong Provincial Dermatology Hospital, Guangzhou, China. Electronic address:
An Bras Dermatol 2011 Jul-Aug;86(4 Suppl 1):S76-7
UNOESC, University of Western Santa Catarina, Joacaba, SC, Brazil.
Flegel's disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small reddish-brown asymptomatic hyperkeratotic papules usually located on the lower extremities. The histopathological features are hyperorthokeratosis, epidermal atrophy and band-like inflammatory infiltrate in the superficial dermis. Treatment is generally ineffective. Read More