Curr Opin Chem Biol 2012 Aug 9;16(3-4):409-14. Epub 2012 Jul 9.
Biomedical Diagnostics Institute, National Centre for Sensor Research, School of Physical Sciences, Dublin City University, Ireland.
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Expert Rev Mol Diagn 2012 May;12(4):407-21
Biomedical Diagnostics Institute, National Centre for Sensor Research, School of Physical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland.
Microfluidic systems for cell separation and analysis have attracted increasing research activity over the past decades. In particular, the prospect of integrating all steps from sample preparation to assay readout in a single microfluidic cartridge, which is inserted into a compact, portable and potentially low-cost instrument, bears great promise to leverage next-generation diagnostic products and to advance life-science research with novel cell and particle manipulation, and analysis tools. Within the range of microfluidic actuation principles available, the centrifugal force is exceptionally well suited for cell handling due to its rotationally induced 'artificial gravity field', which can be varied over several orders of magnitude and which can manipulate bioparticles even in the absence of flow. Read More
Chem Soc Rev 2015 Oct 2;44(17):6187-229. Epub 2015 Jun 2.
Hahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Centrifugal microfluidics has evolved into a mature technology. Several major diagnostic companies either have products on the market or are currently evaluating centrifugal microfluidics for product development. The fields of application are widespread and include clinical chemistry, immunodiagnostics and protein analysis, cell handling, molecular diagnostics, as well as food, water, and soil analysis. Read More
Lab Chip 2010 Jul 28;10(14):1758-73. Epub 2010 May 28.
University of California, Irvine, Irvine, CA 92697, USA.
The centrifugal microfluidic platform has been a focus of academic and industrial research efforts for almost 40 years. Primarily targeting biomedical applications, a range of assays have been adapted on the system; however, the platform has found limited commercial success as a research or clinical tool. Nonetheless, new developments in centrifugal microfluidic technologies have the potential to establish wide-spread utilization of the platform. Read More
Lab Chip 2007 Sep 27;7(9):1094-110. Epub 2007 Jul 27.
HSG-IMI - Institute for Micromachining and Information Technology, 78052 Villingen-Schwenningen, Germany.
We review microfluidic platforms that enable the miniaturization, integration and automation of biochemical assays. Nowadays nearly an unmanageable variety of alternative approaches exists that can do this in principle. Here we focus on those kinds of platforms only that allow performance of a set of microfluidic functions--defined as microfluidic unit operations-which can be easily combined within a well defined and consistent fabrication technology to implement application specific biochemical assays in an easy, flexible and ideally monolithically way. Read More