Genetics of type 2 diabetes in European populations.

J Diabetes 2012 Sep;4(3):203-12

Department of Nutrition Epidemiology, Harvard School of Public Health, Boston, MA, USA.

Type 2 diabetes (T2D) has become a leading health problem throughout the world. It is caused by environmental and genetic factors, as well as interactions between the two. However, until very recently, the T2D susceptibility genes have been poorly understood. During the past 5 years, with the advent of genome-wide association studies (GWAS), a total of 58 T2D susceptibility loci have been associated with T2D risk at a genome-wide significance level (P < 5 × 10(-8) ), with evidence showing that most of these genetic variants influence pancreatic β-cell function. Most novel T2D susceptibility loci were identified through GWAS in European populations and later confirmed in other ethnic groups. Although the recent discovery of novel T2D susceptibility loci has contributed substantially to our understanding of the pathophysiology of the disease, the clinical utility of these loci in disease prediction and prognosis is limited. More studies using multi-ethnic meta-analysis, gene-environment interaction analysis, sequencing analysis, epigenetic analysis, and functional experiments are needed to identify new susceptibility T2D loci and causal variants, and to establish biological mechanisms.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1753-0407.2012.00224.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422419PMC
September 2012
4 Reads

Article Mentions


Provided by Crossref Event Data
crossref
Crossref: Crossref
November 29, 2012, 7:00 pm EST

Publication Analysis

Top Keywords

t2d susceptibility
16
susceptibility loci
12
novel t2d
8
type diabetes
8
european populations
8
t2d
7
susceptibility
5
loci
5
groups discovery
4
disease clinical
4
confirmed ethnic
4
ethnic groups
4
discovery novel
4
loci contributed
4
pathophysiology disease
4
contributed understanding
4
populations confirmed
4
clinical utility
4
understanding pathophysiology
4
function novel
4

Similar Publications