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IEEE Trans Med Imaging 2021 Mar 2;PP. Epub 2021 Mar 2.

Contrast-enhanced ultrasound (CEUS) has emerged as a popular imaging modality in thyroid nodule diagnosis due to its ability to visualize vascular distribution in real time. Recently, a number of learning-based methods are dedicated to mine pathological-related enhancement dynamics and make prediction at one step, ignoring a native diagnostic dependency. In clinics, the differentiation of benign or malignant nodules always precedes the recognition of pathological types. Read More

BMJ Case Rep 2021 Mar 1;14(3). Epub 2021 Mar 1.

Endocrinology, Diabetes, and Metabolism Department, Centro Hospitalar Universitário Lisboa Norte EPE, Lisboa, Portugal.

IgG4-thyroid-related disease (TRD) represents an uncommon spectrum of diseases, with four subcategories established so far, IgG4-related Hashimoto's thyroiditis, fibrosing variant of Hashimoto's thyroiditis, Riedel's thyroiditis and Graves disease with elevated IgG4 levels. We report the case of a 59-year-old woman presenting with painless cervical swelling and hypothyroidism. Thyroid gland was enlarged and distinctively very hard, with reduced mobility. Read More

J Endocrinol Invest 2021 Mar 1. Epub 2021 Mar 1.

Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No.123, Ta-Pei Road, Niao-Song District, Kaohsiung City 833, Taiwan.

Background: This study aimed to identify the potential circulating biomarkers of protein, mRNAs, and long non-coding RNAs (lncRNAs) to differentiate the papillary thyroid cancers from benign thyroid tumors.

Methods: The study population of 100 patients was classified into identification (10 patients with papillary thyroid cancers and 10 patients with benign thyroid tumors) and validation groups (45 patients with papillary thyroid cancers and 35 patients with benign thyroid tumors). The Sengenics Immunome Protein Array-combined data mining approach using the Open Targets Platform was used to identify the putative protein biomarkers, and their expression validated using the enzyme-linked immunosorbent assay. Read More

Endocr Pract 2020 Dec 15. Epub 2020 Dec 15.

Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address:

Objective: To compare the thyroid autoantibody status of patients with papillary thyroid cancer (PTC) and benign nodular goiter as well as possible associations between thyroid autoantibodies and clinicopathologic features of PTC.

Methods: A total of 3934 participants who underwent thyroidectomy were enrolled in this retrospective study. Patients were divided into PTC and benign nodule groups according to pathological diagnosis. Read More

Ann R Coll Surg Engl 2021 Mar;103(3):223-230

Department of Thyroid Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Introduction: Hashimoto's thyroiditis (HT) is one of the most common immune-mediated diseases. It makes thyroid surgery more complicated and difficult because there may be adhesions between the thyroid gland and surrounding structures. However, it is still controversial whether HT patients carry a high risk for postoperative complications of thyroid surgery. Read More