The association between sleep apnea and young adults with hypertension.

Laryngoscope 2012 Oct 2;122(10):2337-42. Epub 2012 Jul 2.

Department of Otorhinolaryngology-Head and Neck Surgery, Beserah Health Polyclinic, Kuantan, Pahang, Malaysia.

Objectives/hypothesis: To study the association between sleep apnea and hypertension in a younger age group than previously studied, adding upper airway sizes at endoscopy as important compounding variables not often included in the past.

Study Design: Case control.

Methods: We analyzed data on sleep-disordered breathing (based on polysomnography tests), body mass index (BMI), neck circumference, upper airway endoscopy sizes, and habitus and health history in 120 hypertensive and 120 nonhypertensive participants in a clinic-based setting. Independent t test, χ(2) , multivariate analysis, and binary logistic regression models were used for case-control comparison.

Results: The mean age of the participants was 27 years; 67.5% were male. The incidence and severity of sleep apnea were significantly higher in the hypertensive than the control subjects. Persons with hypertension had an OR of 2.7 times of having comorbid sleep apnea than patients without hypertension (95% confidence interval [CI] 1.2-6.1). Persons with sleep apnea (AHI [apnea-hypopnea index] ≥ 5) had an OR of 2.76 (95% CI 1.57-4.86), and persons with severe sleep apnea (AHI ≥ 30) had an OR 7.94 (95% CI 4.21-15.33) for having hypertension than did persons without sleep apnea. Although adjustments for the compounding factors, particularly BMI, decreased the OR to a large degree, subjects with severe sleep apnea were still 72% more likely to have hypertension than subjects without sleep apnea.

Conclusions: Sleep apnea is related to hypertension in young adults aged 18 to 40 years. The association was more pronounced with the increasing severity of sleep apnea. Screening for sleep apnea should be considered in young adults with hypertension.

Download full-text PDF

Source Listing
October 2012

Publication Analysis

Top Keywords

sleep apnea
young adults
persons sleep
severe sleep
upper airway
apnea ahi
apnea hypertension
severity sleep
association sleep
adults hypertension
binary logistic
apnea adjustments
adjustments compounding
421-1533 hypertension
logistic regression
multivariate analysis
analysis binary

Similar Publications

[A multi-center study on the association between sleep apnea and prevalence of hypertension].

Zhonghua Jie He He Hu Xi Za Zhi 2007 Dec;30(12):894-7

Department of Respiratory Medicine, Tianjin Medical University General Hospital, Tianjin, China.

Objective: To investigate the prevalence of hypertension among sleep apnea patients and the associated factors.

Methods: A total of 2297 patients (male 1310, female 211) from 20 teaching hospitals were enrolled in this study. Medical history interview, blood pressure measurement and an in-hospital polysomnogram were performed for all the patients. Read More

View Article and Full-Text PDF
December 2007

Prospective study of the association between sleep-disordered breathing and hypertension.

N Engl J Med 2000 May;342(19):1378-84

Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705, USA.

Background: Sleep-disordered breathing is prevalent in the general population and has been linked to chronically elevated blood pressure in cross-sectional epidemiologic studies. We performed a prospective, population-based study of the association between objectively measured sleep-disordered breathing and hypertension (defined as a laboratory-measured blood pressure of at least 140/90 mm Hg or the use of antihypertensive medications).

Methods: We analyzed data on sleep-disordered breathing, blood pressure, habitus, and health history at base line and after four years of follow-up in 709 participants of the Wisconsin Sleep Cohort Study (and after eight years of follow-up in the case of 184 of these participants). Read More

View Article and Full-Text PDF
May 2000

Craniofacial abnormalities in Chinese patients with obstructive and positional sleep apnea.

Sleep Med 2008 May 19;9(4):403-10. Epub 2007 Jul 19.

Chest Department, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC.

Background: Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of a complete or partial collapse of the upper airway during sleep. Traditionally, the disease is diagnosed by overnight polysomnography. Studies have shown correlation between parameters of cephalometry and severity of sleep apnea. Read More

View Article and Full-Text PDF
May 2008

Sleep apnea and epilepsy: who's at risk?

Epilepsy Behav 2012 Nov 24;25(3):363-7. Epub 2012 Oct 24.

Sleep Disorders and Epilepsy Centers, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Obstructive sleep apnea (OSA) is highly prevalent, affecting 25% of men and 10% of women. Treatment reduces seizures in some patients. Awareness of the comorbidity of sleep disturbances in epilepsy has been increasing. Read More

View Article and Full-Text PDF
November 2012