TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?

Front Immunol 2012 4;3:129. Epub 2012 Jun 4.

Department of Pathology and Laboratory Medicine, University of British Columbia Vancouver, BC, Canada.

In 2005 a newly discovered T helper cell subset that secreted interleukin (IL)-17 became the center of attention in immunology. Initial studies painted Th17 cells as the culprit for destruction in many different autoimmune and auto-inflammatory diseases. Subsequently, the discovery of patients with primary immunodeficiencies in the IL-17 pathway taught us that Th17 cells have a critical role in defense against certain fungal and bacterial infections. Moreover, the paradoxical exacerbation of Crohn's disease in the clinical trials of a Secukinumab (AIN457), a fully human neutralizing antibody to IL-17A, has cast into doubt a universal pro-inflammatory and harmful role for Th17 cells. Evidence now suggests that depending on the environment Th17 cells can alter their differentiation program, ultimately giving rise to either protective or pro-inflammatory cells. In this review we will summarize the evidence from patients with immunodeficiencies, autoimmune, or auto-inflammatory diseases that teaches us how the pro-inflammatory versus protective function of Th17 cells varies within the context of different human diseases.

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Source
http://dx.doi.org/10.3389/fimmu.2012.00129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366440PMC
August 2012
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