The free-radical theory of ageing--older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support.

Bioessays 2012 Aug 29;34(8):692-700. Epub 2012 May 29.

Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle Upon Tyne, UK.

The continuing viability of the free-radical theory of ageing has been questioned following apparently incompatible recent results. We show by modelling positional effects of the generation and primary targets of reactive oxygen species that many of the apparently negative results are likely to be misleading. We conclude that there is instead a need to look more closely at the mechanisms by which free radicals contribute to age-related dysfunction in living systems. There also needs to be deeper understanding of the dynamics of accumulation and removal of the various kinds of molecular damage, in particular mtDNA mutations. Finally, the expectation that free-radical damage on its own might cause ageing needs to be relinquished in favour of the recognition that the free-radical theory is just one of the multiple mechanisms driving the ageing process.

Download full-text PDF

Source
http://dx.doi.org/10.1002/bies.201200014DOI Listing
August 2012
5 Reads

Publication Analysis

Top Keywords

free-radical theory
12
primary targets
8
positional effects
8
modelling positional
8
oxygen species
4
living systems
4
dysfunction living
4
systems deeper
4
deeper understanding
4
accumulation removal
4
dynamics accumulation
4
understanding dynamics
4
age-related dysfunction
4
species negative
4
free-radical
4
conclude closely
4
misleading conclude
4
mechanisms free
4
free radicals
4
contribute age-related
4

Similar Publications