Search our Database of Scientific Publications and Authors

I’m looking for a

    Details and Download Full Text PDF:
    Antimicrobial activity of the extracts from Benchalokawichian remedy and its components.

    J Med Assoc Thai 2011 Dec;94 Suppl 7:S172-7
    Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
    Background: Infectious diseases cause serious health problems worldwide due to multiresistant bacterial strains. Thai traditional formula such as Benchalokawichian remedy has been used to relieve fever, common cold and influenza. The remedy has been scientifically proved for antipyretic and antiseptic activities. However; the remedy and its components have not been fully studied for antimicrobial activity against pathogenic bacteria.

    Objective: To determine antimicrobial activity of extracts from Benchalokawichian remedy and its components against clinical isolates by disk diffusion method.

    Material And Method: The bacterial strains used in the present study were clinical isolates from Thammasat Hospital, Thailand. The ethanolic and water extracts of Benchalokawichian remedy and its components were screened for antimicrobial activity. The tests were performed in triplicate. The results were recorded by measuring diameter of growth inhibition zone. Means +/- SD of the obtained results were calculated.

    Results: The results of antimicrobial activity demonstrated that the ethanolic extracts of Benchalokawichian remedy and its components were effective against Candida albicans, Gram positive and Gram negative bacteria except some isolates. Tiliacora triandra and Clerodendrum petasites exhibited the most effective antimicrobial activity among other ethanolic extracts. The water extracts of Capparis micracantha, Tiliacora triandra and Harrisonia perforata were able to inhibit the tested strains. Both etahnolic and water extracts of Tiliacora triandra were the only one component of Benchalokawichian remedy that could inhibit the growth of C. albicans.

    Conclusion: The present study provides basic knowledge of the antimicrobial activity of Benchalokawichian remedy and its components. Tiliacora triandra and Clerodendrum petasites were the most effective antimicrobial activity among other ethanolic extracts. They are potential candidates to produce medicinal formula for alternative medicine. Further study on minimum inhibitory concentration and minimum bactericidal concentration assay will be carried out in order to obtain more detailed insightful knowledge to develop medicinal products for treatment of bacterial infection and other infectious diseases.

    Similar Publications

    Antibacterial activity of crude extracts of prasaprohyai formula and its components against pathogenic bacteria.
    J Med Assoc Thai 2011 Dec;94 Suppl 7:S153-61
    Faculty of Medicine, Thammasat University, Klongluang, Pathum Thani, Thailand.
    Background: Prasaprohyai formula is a Thai Traditional Medicine which has been used for reducing feverish in child. Fever is a symptom resulting from various infections and diseases. The major cause of fever is bacterial and viral infections. Read More
    Evaluation of extracts of Anthocleista djalonensis, Nauclea latifolia and Uvaria afzalii for activity against bacterial isolates from cases of non-gonococcal urethritis.
    J Ethnopharmacol 2004 May;92(1):135-44
    Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria.
    Whole root preparations of three Nigerian medicinal plants, Anthocleista djalonensis, Nauclea latifolia and Uvaria afzalii, used traditionally in combination treatment of sexually transmitted diseases (STD), were extracted by maceration in ethanol, cold and hot water, respectively. The extracts were tested, by agar diffusion and macrobroth dilution methods, for activity against five strains of Staphylococcus aureus and two of Escherichia coli isolated from cases of STD and or urethritis. Four typed bacterial strains, S aureus ATCC 12600, Bacillus subtilis ATCC 6051, Pseudomonas aeruginosa ATCC 10145 and Escherichia coli ATCC 117755 were included as reference organisms. Read More
    Inhibitory Effect on β -Hexosaminidase Release from RBL-2H3 Cells of Extracts and Some Pure Constituents of Benchalokawichian, a Thai Herbal Remedy, Used for Allergic Disorders.
    Evid Based Complement Alternat Med 2014 16;2014:828760. Epub 2014 Dec 16.
    Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Rangsit Campus, Khlong Luang, Pathum Thani 12120, Thailand ; Center of Excellence on Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Rangsit Campus, Khlong Luang, Pathum Thani 12120, Thailand.
    Introduction. Benchalokawichian (BCW), a Thai traditional herbal formulation, has long been used as antipyretic and to treat skin disorders. It comprises roots from five herbs: Ficus racemosa, Capparis micracantha, Clerodendrum petasites, Harrisonia perforata, and Tiliacora triandra. Read More