Expert Rev Mol Diagn 2012 May;12(4):407-21
Biomedical Diagnostics Institute, National Centre for Sensor Research, School of Physical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland.
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Curr Opin Chem Biol 2012 Aug 9;16(3-4):409-14. Epub 2012 Jul 9.
Biomedical Diagnostics Institute, National Centre for Sensor Research, School of Physical Sciences, Dublin City University, Ireland.
Over the past two decades, centrifugal microfluidic systems have successfully demonstrated their capability for robust, high-performance liquid handling to enable modular, multi-purpose lab-on-a-chip platforms for a wide range of life-science applications. Beyond the handling of homogeneous liquids, the unique, rotationally controlled centrifugal actuation has proven to be specifically advantageous for performing cell and particle handling and assays. In this review we discuss technologies to implement two important steps for cell handling, namely separation and capturing/counting. Read More
Chem Soc Rev 2015 Oct 2;44(17):6187-229. Epub 2015 Jun 2.
Hahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Centrifugal microfluidics has evolved into a mature technology. Several major diagnostic companies either have products on the market or are currently evaluating centrifugal microfluidics for product development. The fields of application are widespread and include clinical chemistry, immunodiagnostics and protein analysis, cell handling, molecular diagnostics, as well as food, water, and soil analysis. Read More
Lab Chip 2010 Jul 28;10(14):1758-73. Epub 2010 May 28.
University of California, Irvine, Irvine, CA 92697, USA.
The centrifugal microfluidic platform has been a focus of academic and industrial research efforts for almost 40 years. Primarily targeting biomedical applications, a range of assays have been adapted on the system; however, the platform has found limited commercial success as a research or clinical tool. Nonetheless, new developments in centrifugal microfluidic technologies have the potential to establish wide-spread utilization of the platform. Read More
Chem Soc Rev 2010 Mar 25;39(3):1153-82. Epub 2010 Jan 25.
HSG-IMIT-Institut für Mikro- und Informationstechnik, Wilhelm-Schickard-Strasse 10, 78052 Villingen-Schwenningen, Germany.
This critical review summarizes developments in microfluidic platforms that enable the miniaturization, integration, automation and parallelization of (bio-)chemical assays (see S. Haeberle and R. Zengerle, Lab Chip, 2007, 7, 1094-1110, for an earlier review). Read More