Molecular epidemiology of geographically dispersed Vibrio cholerae, Kenya, January 2009-May 2010.

Authors:
Dr Ahmed Abade Mohamed, PhD
Dr Ahmed Abade Mohamed, PhD
Tanzania Field Epidemiology and Laboratory Training Program
Medical Epidemiologist
infectious disease
Dar es Salaam, East Africa | Tanzania, United Republic of

Emerg Infect Dis 2012 Jun;18(6):925-31

Field Epidemiology and Laboratory TrainingProgram, Nairobi, Kenya.

Numerous outbreaks of cholera have occurred in Kenya since 1971. To more fully understand the epidemiology of cholera in Kenya, we analyzed the genetic relationships among 170 Vibrio cholerae O1 isolates at 5 loci containing variable tandem repeats. The isolates were collected during January 2009-May 2010 from various geographic areas throughout the country. The isolates grouped genetically into 5 clonal complexes, each comprising a series of genotypes that differed by an allelic change at a single locus. No obvious correlation between the geographic locations of the isolates and their genotypes was observed. Nevertheless, geographic differentiation of the clonal complexes occurred. Our analyses showed that multiple genetic lineages of V. cholerae were simultaneously infecting persons in Kenya. This finding is consistent with the simultaneous emergence of multiple distinct genetic lineages of V. cholerae from endemic environmental reservoirs rather than recent introduction and spread by travelers.

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Source
http://wwwnc.cdc.gov/eid/article/18/6/11-1774_article.htm
Publisher Site
http://dx.doi.org/10.3201/eid1806.111774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358164PMC
June 2012
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