Inactivation of X-linked tumor suppressor genes in human cancer.

Future Oncol 2012 Apr;8(4):463-81

Division of Immunotherapy, Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

Cancer cells silence autosomal tumor suppressor genes by Knudson's two-hit mechanism in which loss-of-function mutations and then loss of heterozygosity occur at the tumor suppressor gene loci. However, the identification of X-linked tumor suppressor genes has challenged the traditional theory of 'two-hit inactivation' in tumor suppressor genes, introducing the novel concept that a single genetic hit can cause loss of tumor suppressor function. The mechanism through which these genes are silenced in human cancer is unclear, but elucidating the details will greatly enhance our understanding of the pathogenesis of human cancer. Here, we review the identification of X-linked tumor suppressor genes and discuss the potential mechanisms of their inactivation. In addition, we also discuss how the identification of X-linked tumor suppressor genes can potentially lead to new approaches in cancer therapy.

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/fon.12.26
Publisher Site
http://dx.doi.org/10.2217/fon.12.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369797PMC
April 2012
3 Reads

Publication Analysis

Top Keywords

tumor suppressor
32
suppressor genes
24
x-linked tumor
16
human cancer
12
identification x-linked
12
suppressor
8
tumor
8
genes
7
cancer
5
loss tumor
4
mechanism genes
4
suppressor function
4
function mechanism
4
cancer unclear
4
unclear elucidating
4
hit loss
4
silenced human
4
genes silenced
4
inactivation' tumor
4
'two-hit inactivation'
4

References

(Supplied by CrossRef)

Similar Publications