ARKIVOC 2011 31;2011(5):34-44. Epub 2010 Oct 31.
Department of Chemistry, Connecticut College, 270 Mohegan Avenue, New London, CT 06320,
This article describes the development of microwave-assisted oxyanionic 5-exo-dig cyclization-Claisen rearrangement sequence as a convenient "one-pot" route to a variety of seven-membered carbocyclic ring systems. This process was used as the key transformation for the construction of several natural products, including frondosins A, B, and C.