Pharm Res 2012 Aug 5;29(8):2047-59. Epub 2012 Apr 5.
Pharma Technical Development Europe (Biologics) Analytics, F. Hoffmann-La Roche Ltd., 4070, Basel, Switzerland.
Int J Mol Sci 2021 Feb 16;22(4). Epub 2021 Feb 16.
Department of Physiology, University of Sydney, Sydney, NSW 2006, Australia.
Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than in female humans and mice and is exacerbated in female estrogen receptor-beta knockout (ER-β-/-) mice. We previously reported that the active vitamin D hormone, 1,25-dihydroxyvitamin D3 (1,25(OH)2D), applied topically protects against the ultraviolet radiation (UV) induction of cutaneous cyclobutane pyrimidine dimers (CPDs) and the suppression of contact hypersensitivity (CHS) in female mice. Here, we compare these responses in female versus male Skh:hr1 mice, in ER-β-/-/-- versus wild-type C57BL/6 mice, and in female ER-blockaded Skh:hr1 mice. Read More
Front Immunol 2020 12;11:599947. Epub 2021 Feb 12.
Institute of Immunology, University of Muenster, Muenster, Germany.
Psoriasis is one of the most common immune-mediated inflammatory skin diseases. Expression and secretion of two pro-inflammatory molecules of the S100-alarmin family, S100A8 and S100A9, in keratinocytes is a hallmark of psoriasis, which is also characterized by an altered differentiation of keratinocytes. Dimers of S100A8/S100A9 (calprotectin) bind to Toll-like receptor 4 and induce an inflammatory response in target cells. Read More
Inorg Chem 2021 Feb 26. Epub 2021 Feb 26.
Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química (CISQ), Complejo Científico Tecnológico, 26004 Logroño, Spain.
An in-depth study of the molecular rearrangement of the complex [Au(-adeninate)(PTA)] (), promoted in aqueous solution, is presented. This complex, which has been previously described as forming dimers in its crystalline form, is also demonstrated as being able to assemble into an infinite Au···Au chain polymer. The structural motifs are tentatively related to the dramatic modification of the photoemissive properties of in water solution at long times, with the aid of UV-vis and photoluminescence measurements, PGSE-NMR, and theoretical calculations. Read More
Platelets 2021 Feb 26:1-8. Epub 2021 Feb 26.
Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
GPVI is a critical signaling receptor responsible for collagen-induced platelet activation and a promising anti-thrombotic target in conditions such as coronary artery thrombosis, ischemic stroke, and atherothrombosis. This is due to the ability to block GPVI while having minimal effects on hemostasis, making it a more attractive target over current dual-antiplatelet therapy (DAPT) with acetyl salicylic acid and P2Y inhibitors where bleeding can be a problem. Our current understanding of how the structure of GPVI relates to function is inadequate and recent studies contradict each other. Read More
Blood Adv 2021 Feb;5(4):1037-1049
Department of Molecular Medicine.
Light chain (LC) amyloidosis (AL) involves the toxic aggregation of amyloidogenic immunoglobulin LCs secreted from a clonal expansion of diseased plasma cells. Current AL treatments use chemotherapeutics to ablate the AL plasma cell population. However, no treatments are available that directly reduce the toxic LC aggregation involved in AL pathogenesis. Read More