Bioanalysis 2012 Mar;4(6):651-60
ABL, Groningen, The Netherlands.
J Clin Epidemiol 2021 Apr 14. Epub 2021 Apr 14.
Department of Epidemiology and Data Science, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Objectives: This article provides GRADE guidance on how authors of evidence syntheses and health decision makers, including guideline developers, can rate the certainty across a body of evidence for comparative test accuracy questions.Study Design And Setting: This guidance extends the previously published GRADE guidance for assessing certainty of evidence for test accuracy to scenarios in which two or more index tests are compared. Through an iterative brainstorm-discussion-feedback process within the GRADE working group, we developed a guidance accompanied by practical examples. Read More
Regul Toxicol Pharmacol 2021 Apr 13:104926. Epub 2021 Apr 13.
Brazilian Health Regulatory Agency, ANVISA, Brasilia, Brazil.
The ICH M7(R1) guideline describes a framework to assess the carcinogenic risk of mutagenic and carcinogenic pharmaceutical impurities following less-than-lifetime (LTL) exposures. This LTL framework is important as many pharmaceuticals are not administered for a patient's lifetime and as clinical trials typically involve LTL exposures. While there has been regulatory caution about applying LTL concepts to cohort of concern (COC) impurities such as N-nitrosamines, ICH M7 does not preclude this and indeed literature data suggests that the LTL framework will be protective of patient safety for N-nitrosamines. Read More
Expert Rev Clin Pharmacol 2021 Apr 16. Epub 2021 Apr 16.
University of Pecs, Clinical Centre, University Emergency Department, Pécs, Ifjúság útja 13, Hungary.
Introduction: : The pooled worldwide prevalence of low-back pain related presentations in primary care varies between 6.8% and 28.4% in the high-income countries rendering it a major healthcare/economy problem. Read More
Infect Drug Resist 2021 30;14:1283-1293. Epub 2021 Mar 30.
Royal Marsden Hospital and Institute of Cancer Research, Sutton, SM2 5PT, UK.
Febrile neutropenia (FN) is a frequent complication of cancer treatment in children. Owing to the potential for overwhelming bacterial sepsis, the recognition and management of FN requires rapid implementation of evidenced-based management protocols. Treatment paradigms have progressed from hospitalisation with broad spectrum antibiotics for all patients, through to risk adapted approaches to management. Read More
J Gen Intern Med 2021 Apr 7. Epub 2021 Apr 7.
Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Background: In 2015, the US Preventive Services Task Force (USPSTF) revised clinical recommendations to more broadly recommend abnormal blood glucose screening and more clearly recommend referral to behavioral interventions for adults with prediabetes.Objective: To assess the effects of the 2015 USPSTF recommendation changes on abnormal blood glucose screening and referral to behavioral interventions, and to examine physicians' perceptions of the revised recommendation.Design: We utilized a sequential, dependent mixed-methods triangulation design. Read More