Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis.

Authors:
Monica K Mann
Monica K Mann
Blood Research Institute
Avijit Ray, PhD
Avijit Ray, PhD
AbbVie
Senior Scientist II
Immunology, Immuno-oncology, Autoimmunity and Inflammation, Immune tolerance
North Chicago, IL | United States
Sreemanti Basu
Sreemanti Basu
Blood Research Institute
United States
Christopher L Karp
Christopher L Karp
Cincinnati Children's Hospital Research Foundation
United States
Bonnie N Dittel
Bonnie N Dittel
Blood Research Institute

Autoimmunity 2012 Aug 19;45(5):388-99. Epub 2012 Apr 19.

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53201-2178, USA.

A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal model of the human autoimmune disease multiple sclerosis (MS), has been established. In the first role, B cells contribute to the pathogenesis of EAE through the production of anti-myelin antibodies that contribute to demyelination. On the contrary, B cells have also been shown to have protective functions in that they play an essential role in the spontaneous recovery from EAE. In this review, we summarize studies conducted in a number of species demonstrating the conditions under which B cells are pathogenic in EAE. We also discuss the phenotype and anti-inflammatory mechanisms of regulatory B cells.

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Source
http://dx.doi.org/10.3109/08916934.2012.665523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639139PMC

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August 2012
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