Carcinogenesis 2009 May 25;30(5):793-8. Epub 2009 Mar 25.
Medical Oncology and Hematology, Biostatistics, Princess Margaret Hospital and Department of Medicine, Dalla Lama School of Public Health and University of Toronto, Ontario, Canada.
The matrix metalloproteinase (MMP) family degrade extracellular matrix and mediate pathways including apoptosis, angiogenesis and immunity. We studied the association between four MMP polymorphisms within three MMP genes and esophageal adenocarcinoma (EA) risk and prognosis. A total of 313 EA cases and 455 age and gender frequency-matched controls were genotyped for MMP1 1G/2G, MMP3 6A/5A, MMP12 -82A/G and MMP12 1082A/G. Read More