Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1α (HIF-1α).

Authors:
Yueh-Ling Hsieh Li-Wei Chou Pei-Lin Chang Chen-Chia Yang Mu-Jung Kao Chang-Zern Hong

J Comp Neurol 2012 Sep;520(13):2903-16

Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan 40402.

Nerve inflammation plays an important role in the development and progression of neuropathic pain after chronic constrictive injury (CCI). Recent studies have indicated that hypoxia-inducible factor 1α (HIF-1α) is crucial in inflammation. Low-level laser therapy has been used in treating musculoskeletal pain, but rare data directly support its use for neuropathic pain. We investigated the effects of low-level laser on the accumulation of HIF-1α, tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) in controlling neuropathic pain, as well as on the activation of vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) in promoting functional recovery in a rat CCI model. CCI was induced by placing four loose ligatures around the sciatic nerve of rats. Treatments of low-level laser (660 nm, 9 J/cm(2)) or sham irradiation (0 J/cm(2)) were performed at the CCI sites for 7 consecutive days. The effects of laser in animals with CCI were determined by measuring the mechanical paw withdrawal threshold, as well as the sciatic, tibial, and peroneal function indices. Histopathological and immunoassay analyses were also performed. Low-level laser therapy significantly improved paw withdrawal threshold and the sciatic, tibial, and peroneal functional indices after CCI. The therapy also significantly reduced the overexpressions of HIF-1α, TNF-α, and IL-1β, and increased the amounts of VEGF, NGF, and S100 proteins. In conclusion, a low-level laser could modulate HIF-1α activity. Moreover, it may also be used as a novel and clinically applicable therapeutic approach for the improvement of tissue hypoxia/ischemia and inflammation in nerve entrapment neuropathy, as well as for the promotion of nerve regeneration. These findings might lead to a sufficient morphological and functional recovery of the peripheral nerve.

Download full-text PDF

 Source
http://dx.doi.org/10.1002/cne.23072DOI Listing
September 2012

Publication Analysis

Top Keywords

low-level laser
24
neuropathic pain
16
laser therapy
12
1α hif-1α
8
factor 1α
8
paw withdrawal
8
sciatic tibial
8
tibial peroneal
8
growth factor
8
functional recovery
8
withdrawal threshold
8
hypoxia-inducible factor
8
cci
6
nerve
6
low-level
6
laser
6
pain
5
hif-1α
5
animals cci
4
cci determined
4

Keyword Occurance

Similar Publications

Photobiomodulation using LLLT and LED of cells involved in osseointegration and peri-implant soft tissue healing.

Authors:
Carlos Alberto Rech Taisa Nogueira Pansani Lais Medeiros Cardoso Isabela Massaro Ribeiro Yara Teresinha Correa Silva-Sousa Carlos Alberto de Souza Costa Fernanda Gonçalves Basso

Lasers Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Universidade de Ribeirão Preto, UNAERP, Ribeirão Preto, SP, Brazil.

This study evaluated the influence of photobiomodulation (PBM) using low-level laser therapy (PBM/LLLT) or light-emitting diode (PBM/LED) therapy on peri-implant tissue healing. A laboratory model was used to assess the adhesion and metabolism of osteoblasts (SaOs-2), human gingival fibroblasts (HGF), and normal oral keratinocytes (NOK) seeded on a titanium (Ti) surface. After seeding the cells on disks of Ti placed in wells of 24-well plates, three irradiations were performed every 24 h at energy density of 3 J/cm. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Use of high- and low-intensity lasers in the treatment of dentin hypersensitivity: A literature review.

Authors:
Thamyres-Maria-Silva Simões Kamila-Cibele-Bezerra Melo José-de Alencar Fernandes-Neto Ana-Luzia-Araújo Batista Maria-das Graças-Barbosa da Silva Alieny-Cristina-Duarte Ferreira Juliane-Alves de Sousa Maria-Helena-Chaves-de Vasconcelos Catão

J Clin Exp Dent 2021 Apr 1;13(4):e412-e417. Epub 2021 Apr 1.

PhD Professor, Postgraduate Program in Dentistry, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil.

Background: Dentin hypersensitivity (DH) is defined as an exaggerated sensitivity of vital dentin exposed to thermal, chemical and tactile stimuli. This study aimed to evaluate, through a literature review, the applicability of high- and low-intensity lasers in the treatment of DH for the past 10 years, as well as its therapeutic potential.

Material And Methods: The electronic databases MEDLINE/PubMed and LILACS were searched using the descriptors ("Dentin Sensitivity" OR "Dentin Hypersensitivity") AND ("Low-Level Therapy" OR Laser), for articles published between 2010 and 2020. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Use of 1064nm Nd:YAG Laser Biostimulation for Immediate Reversal of a Long-Standing Paresthesia of the Superior Labial Branch of the Infraorbital Nerve Following a Root Coverage Procedure: A Case Report.

Authors:
Alan M Timko

Clin Adv Periodontics 2021 Apr 9. Epub 2021 Apr 9.

Diplomate of the American Board of Periodontology, Private Practice, 9401 McKnight Rd., Suite 301-A, Pittsburgh, PA, 15237.

Introduction: Paresthesia is a common cause of dental malpractice litigation. Symptoms range from minimal to severely affecting the quality of life. Effective treatments of post-traumatic paresthesias are scarce. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial.

Authors:
Özer Alkan Yeşim Kaya Esra Yüksek Ahmet Ufuk Kömüroglu

Turk J Orthod 2021 1;34(1):26-30. Epub 2021 Mar 1.

Health Service Vocational School of Higher Education, Van, Turkey.

Objective: This study aims to evaluate the effect of low-level laser therapy on peri-miniscrew fluid prostaglandin E2 (PGE2) and substance P (SP) levels during orthodontic treatment.

Methods: A total of 15 individuals were included in this study. Miniscrews were inserted to the inter-radicular region of the maxillary right and left second premolar and the first molar teeth, and diode lasers were randomly applied to the right or left side. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Long-Term Effectiveness of Combined Intermittent Pneumatic Compression Plus Low-Level Laser Therapy in Patients with Postmastectomy Lymphedema: A Randomized Controlled Trial.

Authors:
Erkan Kozanoglu Neslihan Gokcen Sibel Basaran Semra Paydas

Lymphat Res Biol 2021 Apr 7. Epub 2021 Apr 7.

Division of Oncology, Department of Internal Medicine, Cukurova University Faculty of Medicine, Adana, Turkey.

Upper limb lymphedema may be revealed after breast cancer and its treatment. Among different treatment approaches, intermittent pneumatic compression (IPC) therapy and low-level laser therapy (LLLT) are reported as effective modalities in the treatment of postmastectomy upper limb lymphedema (PML). The aim of the current study is to investigate the long-term effectiveness of combined IPC plus LLLT versus IPC therapy alone in patients with PML. Read More

View Article and Full-Text PDF
April 2021
Similar Publications