Rate and breadth of protein evolution are only weakly correlated.

Biol Direct 2012 Feb 15;7. Epub 2012 Feb 15.

Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoi Karetny pereulok 19, Moscow 127994, Russia.

Background: Evolution at a protein site can be characterized from two different perspectives, by its rate and by the breadth of the set of acceptable amino acids.

Results: There is a weak positive correlation between rates and breadths of evolution, both across individual amino acid sites and across proteins.

Conclusions: Rate and breadth are two distinct, and only weakly correlated, characteristics of protein evolution. The most likely explanation of their positive correlation is heterogeneity of selective constraint, such that less functionally important sites evolve faster and can accept more amino acids.

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Source
http://dx.doi.org/10.1186/1745-6150-7-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331848PMC
February 2012
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