The Nogo-66 receptor family in the intact and diseased CNS.

Cell Tissue Res 2012 Jul 8;349(1):105-17. Epub 2012 Feb 8.

Division of Neurobiochemistry, Biocenter, Innsbruck Medical University, Fritz-Pregl-Str3, 6020 Innsbruck, Austria.

The Nogo-66 receptor family (NgR) consists in three glycophosphatidylinositol (GPI)-anchored receptors (NgR1, NgR2 and NgR3), which are primarily expressed by neurons in the central and peripheral mammalian nervous system. NgR1 was identified as serving as a high affinity binding protein for the three classical myelin-associated inhibitors (MAIs) Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), which limit axon regeneration and sprouting in the injured brain. Recent studies suggest that NgR signaling may also play an essential role in the intact adult CNS in restricting axonal and synaptic plasticity and are involved in neurodegenerative diseases, particularly in Alzheimer's disease pathology through modulation of β-secretase cleavage. Here, we outline the biochemical properties of NgRs and their functional roles in the intact and diseased CNS.

Download full-text PDF

Source
http://link.springer.com/10.1007/s00441-012-1332-9
Publisher Site
http://dx.doi.org/10.1007/s00441-012-1332-9DOI Listing
July 2012

Publication Analysis

Top Keywords

diseased cns
8
receptor family
8
intact diseased
8
nogo-66 receptor
8
axon regeneration
4
regeneration sprouting
4
limit axon
4
omgp limit
4
glycoprotein omgp
4
sprouting injured
4
signaling play
4
studies ngr
4
brain studies
4
myelin glycoprotein
4
injured brain
4
ngr signaling
4
myelin-associated glycoprotein
4
classical myelin-associated
4
three classical
4
protein three
4

Similar Publications