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JCI Insight 2021 Mar 4. Epub 2021 Mar 4.

Department AHFMO, Sapienza University of Rome, Rome, Italy.

During denervation induced muscle atrophy, the loss of neuro-muscular junction (NMJ) integrity and the consequent cessation of nerve signal transmission to muscle, lead to a decline in myofiber size mass and contractile activity. However, the identity of the cell types implicated in the muscle response to nerve injury has not been clearly defined. Here, we describe a subpopulation of muscle resident glial cells activated by loss of NMJ integrity. Read More

Environ Sci Pollut Res Int 2021 Mar 4. Epub 2021 Mar 4.

Image Processing Laboratory, University of Valencia, Paterna Campus, Paterna, Spain.

Satellite images were used to assess surface water quality based on the concentration of chlorophyll a (chla), light penetration measured by the Secchi disk method (SD), and the Cyanobacteria cells number per mL (cyano). For this case study, six reservoirs interconnected were evaluated, comprising the Cantareira System (CS) in São Paulo State (Brazil). The work employed Sentinel-2 images from 2015 to 2018, SNAP image processing software, and the native products conc_chl and kd_z90max, treated using Case 2 Regional Coast Color (C2RCC) atmospheric correction. Read More

Bio Protoc 2020 Jul 20;10(14):e3686. Epub 2020 Jul 20.

Department of Animal Sciences, Purdue University, West Lafayette, United States.

The skeletal muscle is key for body mobility and motor performance, but aging and diseases often lead to progressive loss of muscle mass due to wasting or degeneration of muscle cells. Muscle satellite cells (MuSCs) represent a population of tissue stem cells residing in the skeletal muscles and are responsible for homeostatic maintenance and regeneration of skeletal muscles. Growth, injury, and degenerative signals activate MuSCs, which then proliferate (proliferating MuSCs are called myoblasts), differentiate and fuse with existing multinuclear muscle cells (myofibers) to mediate muscle growth and repair. Read More

J Biomed Sci 2021 Mar 3;28(1):15. Epub 2021 Mar 3.

Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Parow, South Africa.

Although rheumatoid arthritis affects 1% of the global population, the role of rheumatoid cachexia, which occurs in up to a third of patients, is relatively neglected as research focus, despite its significant contribution to decreased quality of life in patients. A better understanding of the cellular and molecular processes involved in rheumatoid cachexia, as well as its potential treatment, is dependent on elucidation of the intricate interactions of the cells involved, such as myoblasts, fibroblasts and macrophages. Persistent RA-associated inflammation results in a relative depletion of the capacity for regeneration and repair in the satellite cell niche. Read More

Cell Rep 2021 Mar;34(9):108809

Institute of Life Sciences (An Autonomous Institute of Department of Biotechnology), Bhubaneswar 751023, India. Electronic address:

Muscle differentiation is a multifaceted and tightly controlled process required for the formation of skeletal muscle fibers. Satellite cells are the direct cellular contributors to muscle repair in injuries or disorders. Here, we show that autotaxin (Atx) expression and activity is required for satellite cell differentiation. Read More