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Bioconjug Chem 2023 Sep 26. Epub 2023 Sep 26.

Department of Chemistry and Institute of Chemical Biology, Molecular Sciences Research Hub, Imperial College London, White City Campus, Wood Lane, London W120BZ, U.K.

Bioconjugates of antibodies and their derivatives radiolabeled with β-emitting radionuclides can be utilized for diagnostic PET imaging. Site-specific attachment of radioactive cargo to antibody delivery vectors provides homogeneous, well-defined immunoconjugates. Recent studies have demonstrated the utility of oxaziridine chemistry for site-specific labeling of methionine residues. Read More

Org Biomol Chem 2023 Sep 26. Epub 2023 Sep 26.

Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B.C., V6T 1Z1, Canada.

Mimics of the complex flavonol glycoside montbretin A in which a flavonol moiety is coupled to a caffeic acid partially peptidic linkers have proved to be potent inhibitors of human pancreatic alpha-amylase with potential as therapeutics for control of blood glucose levels. After exploring optimal linker length, a synthetic route to a version with a branched linker was devised based on the structure of the enzyme/inhibitor complex. The resultant branched inhibitors were shown to retain nanomolar potency even when decorated with polymers as a means of modifying solubility. Read More

Front Oncol 2023 8;13:1257175. Epub 2023 Sep 8.

Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium.

Despite innovations in cancer therapeutics, cancer remains associated with high mortality and is one of biggest health challenges worldwide. Therefore, developing precise cancer imaging and effective treatments is an unmet clinical need. A relatively novel type of therapeutics are heavy chain variable domain antibody fragments (VHHs) derived from llamas. Read More

Front Cell Infect Microbiol 2023 31;13:1153387. Epub 2023 Aug 31.

Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: Colistin, as the antibiotic of "last resort" for carbapenem-resistant , develop resistance during administration of this antimicrobial agent. We identified an NDM-1-producing subsp. (KQSS) strain KQ20605 recovered from a child, which developed resistance to colistin (KQ20786) through acquiring an IS element between the -27 and -26 bp of promoter region after 6-day colistin usage. Read More

Talanta 2023 Sep 19;267:125225. Epub 2023 Sep 19.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, PR China; Theoretical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, PR China; Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun, 130012, PR China. Electronic address:

A surface-enhanced Raman scattering (SERS) strategy combined with a CRISPR/Cas12a system is designed for the amplification-free gene detection of African swine fever virus (ASFV). A SERS sensing probe was fabricated by conjugating plasmonic SERS tags on the magnetic bead (MB) surface with an single-stranded DNA (ssDNA) as a linker. The target ASFV gene-activated Cas12a protein starts the trans-cleavage function on the linker ssDNA, which causes the release of SERS tags, leading to a decrease of the SERS signal detected above the collective MBs. Read More