In vivo polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) in rodent cerebral cortex.

Authors:
Professor David C Martin, PhD, MS, BSE
Professor David C Martin, PhD, MS, BSE
University of Delaware
Professor
Materials Science and Engineering, Polymer Science and Engineering
Newark, DE | United States

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:5412-5

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Maintaining a reliable neural interface is a well-known challenge with implanted neural prostheses. Here we evaluate a method of forming an integrated neural interface through polymerization of PEDOT in vivo. Polymerization resulted in lower impedance and improved recording quality of local field potentials on implanted electrodes in the rat cerebral cortex. Histological analysis by optical microscopy confirmed successful integration of the PEDOT within tissue surrounding implanted electrodes. This technique offers a unique neural interfacing approach with potential to improve the long-term functionality of neural prostheses.

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Source
http://dx.doi.org/10.1109/IEMBS.2011.6091338DOI Listing
June 2012
6 Citations

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