Search our Database of Scientific Publications and Authors

I’m looking for a

    Details and Download Full Text PDF:
    Lack of early pattern stimulation prevents normal development of the alpha (Y) retinal ganglion cell population in the cat.

    J Comp Neurol 2012 Aug;520(11):2414-29
    Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland.
    Binocular deprivation of pattern vision (BD) early in life permanently impairs global motion perception. With the SMI-32 antibody against neurofilament protein (NFP) as a marker of the motion-sensitive Y-cell pathway (Van der Gucht et al. [2001] Cereb. Cortex 17:2805-2819), we analyzed the impact of early BD on the retinal circuitry in adult, perceptually characterized cats (Burnat et al. [2005] Neuroreport 16:751-754). In controls, large retinal ganglion cells exhibited a strong NFP signal in the soma and in the proximal parts of the dendritic arbors. The NFP-immunoreactive dendrites typically branched into sublamina a of the inner plexiform layer (IPL), i.e., the OFF inner plexiform sublamina. In the retina of adult BD cats, however, most of the NFP-immunoreactive ganglion cell dendrites branched throughout the entire IPL. The NFP-immunoreactive cell bodies were less regularly distributed, often appeared in pairs, and had a significantly larger diameter compared with NFP-expressing cells in control retinas. These remarkable differences in the immunoreactivity pattern were typically observed in temporal retina. In conclusion, we show that the anatomical organization typical of premature Y-type retinal ganglion cells persists into adulthood even if normal visual experience follows for years upon an initial 6-month period of BD. Binocular pattern deprivation possibly induces a lifelong OFF functional domination, normally apparent only during development, putting early high-quality vision forward as a premise for proper ON-OFF pathway segregation. These new observations for pattern-deprived animals provide an anatomical basis for the well-described motion perception deficits in congenital cataract patients.
    PDF Download - Full Text Link
    ( Please be advised that this article is hosted on an external website not affiliated with
    Source Status ListingPossible

    Similar Publications

    Binocular pattern deprivation with delayed onset has impact on motion perception in adulthood.
    Neuroscience 2013 11;255:99-109. Epub 2013 Oct 11.
    Laboratory of Neuroplasticity, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Pasteur 3, 02-093 Warsaw, Poland.
    The quality of motion perception depends on visual input during early development. Even 1month of binocular deprivation (BD) from birth impairs motion coherence thresholds when tested in kittens; conversely BD with a 1-month delayed onset does not impair it (Mitchell et al., 2009). Read More
    A neurofilament protein antibody selectively labels a large ganglion cell type in the human retina.
    Brain Res 1992 Jun;582(1):123-8
    Department of Anatomy and Histology, School of Medicine, Flinders University of South Australia, Adelaide.
    An antibody (SMI-32) raised against the non-phosphorylated form of the neurofilament protein triplet (NFP) revealed immunoreactivity in the soma and dendritic arborization of a group of large ganglion cells in the human retina. In addition, a population of smaller somas was also faintly labeled with this antibody in the ganglion cell layer. The completely stained cells amounted to 44,000 and were non-uniformly distributed across the retina with a peak density of 100 cells/mm2 in the retinal periphery. Read More
    "Small-tufted" ganglion cells and two visual systems for the detection of object motion in rabbit retina.
    Vis Neurosci 2005 Jul-Aug;22(4):509-34
    Department of Surgery (Ophthalmology), Brown University, Providence, RI 02903, USA.
    Small-tufted (ST) ganglion cells of rabbit retina are divided into eight types based upon morphology, branching pattern, level of dendritic stratification, and quantitative dimensional analysis. Only one of these types has been previously characterized in Golgi preparations, and four may be discerned in the work of others. Given their small dendritic-field size, and assuming uniform mosaics of each across the retina, ST cells comprise about 45% of all rabbit ganglion cells, and are therefore of major functional significance. Read More
    Pathway-specific maturation, visual deprivation, and development of retinal pathway.
    Neuroscientist 2004 Aug;10(4):337-46
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
    One of the fundamental features of the visual system is the segregation of neural circuits that process increments and decrements of luminance into ON and OFF pathways. In mature retina, the dendrites of retinal ganglion cells (RGCs) in the inner plexiform layer (IPL) of retina are separated into ON or OFF sublamina-specific stratification. At an early developmental stage, however, the dendrites of most RGCs are ramified throughout the IPL. Read More