GRK2 at the control shaft of cellular metabolism.

Authors:
Michele Ciccarelli
Michele Ciccarelli
University of Salerno
Fisciano | Italy
Ersilia Cipolletta
Ersilia Cipolletta
Department of Clinical Medicine
Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy

Curr Pharm Des 2012 ;18(2):121-7

Department of Clinical Medicine and Cardiovascular Science, "Federico II" University of Naples, Italy.

G protein receptor kinase 2 (GRK2) has been for years mainly considered the negative regulator of the cardiac β adrenergic signaling. However GRK2 is a ubiquitous molecule and its kinase activity and scaffold properties brought to several investigations which have evidenced its involvement in pathophysiology of extra-cardiac diseases. Later discoveries, moreover, indicated that this molecule is also able to influence other pathways such as insulin signaling by an inhibitory role similar to what described years before on βAR signaling. The importance of this novel function is in particular related to the possibility that this molecule can regulate the cellular metabolism, modifying the ability of cells to utilize different substrates. This hypothesis has been recently investigated in animal model of Heart Failure, evidencing that upregulation of GRK2 leads to alterations of cardiac glucose metabolism in the early stages of the disease. However GRK2 shows increased level also in the early stages of others chronic disease such as Alzheimer's Disease, indicating that these findings could be possibly applied to others cellular system and supporting the emerging idea of GRK2 as master regulator of cellular metabolism.

Download full-text PDF

Source

Still can't find the full text of the article?

We can help you send a request to the authors directly.
June 2012
3 Reads
9 Citations
3.452 Impact Factor

Publication Analysis

Top Keywords

cellular metabolism
12
early stages
8
grk2
6
stages chronic
4
years βar
4
described years
4
role described
4
βar signaling
4
level early
4
function possibility
4
increased level
4
novel function
4
signaling novel
4
inhibitory role
4
chronic disease
4
indicated molecule
4
molecule influence
4
discoveries indicated
4
diseases discoveries
4
extra-cardiac diseases
4

Similar Publications