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Cureus 2021 Sep 9;13(9):e17849. Epub 2021 Sep 9.

Pathology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

Acrokeratosis paraneoplastica is a rare paraneoplastic skin disease in which there are erythematous violaceous, scaly plaques on the hands, feet, and acral locations. There is a relationship between various carcinomas of the aerodigestive tract and skin eruptions. These were the pioneering work done pertaining to a clinical entity that was showing some inter-relationship between a skin condition and carcinoma anywhere inside the body. Read More

Skin Appendage Disord 2021 Apr 2;7(3):163-172. Epub 2021 Mar 2.

Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.

Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic dermatosis associated with internal malignancies. Clinical presentation is characterized by erythematous or violaceous scaly plaques involving the digits, nose, ears, palms, and soles. Nail changes commonly present concurrently with cutaneous manifestations. Read More

Dermatol Clin 2021 Apr 12;39(2):175-182. Epub 2021 Feb 12.

Nail Disease Centre, Rue des Serbes 42, Cannes 06400, France.

The cutaneous paraneoplastic syndromes are rare and intrinsically devoid of any neoplastic nature. The manifestations on the skin and the nails are due to various mechanisms caused by the tumor, either due to production of bioactive substances or in response to it. These disorders evolve in parallel to the malignancy, in that, they regress when the tumor is removed and reappear in the case of tumor recurrence. Read More

BMJ Case Rep 2020 Dec 13;13(12). Epub 2020 Dec 13.

Dermatology, Wayne State University School of Medicine, Dearborn, Michigan, USA.

Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic skin condition characterised by acral psoriasiform plaques, with a predilection for the nose, ears, hands and feet. It typically presents before the discovery of an internal malignancy and is often misdiagnosed as an inflammatory dermatitis that does not respond to treatment. It is associated with squamous cell carcinoma of the aerodigestive tract and lung, as well as adenocarcinoma of the lung, colon and gastrum. Read More

Clin Case Rep 2020 Nov 15;8(11):2259-2264. Epub 2020 Jul 15.

Radiation Oncology Seidman Cancer Center University Hospitals Cleveland OH USA.

Bazex syndrome is a rare paraneoplastic dermatosis that precedes diagnosis of cancer. Awareness of this syndrome is important, as it allows early detection of underlying malignancy and may prevent misdiagnosis and delays in cancer treatment. Read More