Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions.

Expert Rev Clin Pharmacol 2011 Nov;4(6):729-42

Institute of Pharmacology, Ernst Moritz Arndt University, Friedrich-Loeffler-Stra├če 23, 17487 Greifswald, Germany.

At present, many patients are medicated with various drugs, which are, at the same time, associated with an increased risk of drug-drug interactions (DDIs). Detailed analysis of mechanisms underlying DDIs is the basis of a better prediction of adverse drug events caused by drug interactions. In the last few decades, an involvement of transporters in such processes has been more and more recognized. Indeed, uptake transporters belonging to the organic anion-transporting polypeptide (OATP) family have been shown to interact with a variety of drugs in clinical use. Particularly, the subfamily of OATP1B transporters has been extensively studied, identifying several clinical significant DDIs based on those hepatic uptake transporters. By contrast, the role of OATP2B1 in this context is rather underestimated. Therefore, in addition to known interactions based on OATP1B transporters, we have focused on DDIs probably based on OATP2B1 inhibition in the liver and those possibly owing to the inhibition of OATP2B1-mediated drug absorption in the intestine.

Download full-text PDF

Source
http://dx.doi.org/10.1586/ecp.11.58DOI Listing
November 2011
1 Read

Publication Analysis

Top Keywords

oatp1b transporters
8
ddis based
8
drug-drug interactions
8
uptake transporters
8
transporters
5
variety drugs
4
interact variety
4
family interact
4
oatp family
4
drugs clinical
4
subfamily oatp1b
4
studied identifying
4
extensively studied
4
transporters extensively
4
polypeptide oatp
4
clinical subfamily
4
anion-transporting polypeptide
4
involvement transporters
4
decades involvement
4
interactions decades
4

References

(Supplied by CrossRef)

Caldwell et al.
Toxicol. Pathol. 1995

Reitman et al.
Clin. Pharmacol. Ther. 2011

Suzuki et al.
Semin. Liver Dis. 2000

Kullak-Ublick et al.
J. Hepatol. 1999

Muller et al.
Am. J. Physiol. 1997

Fredriksson et al.
FEBS Lett. 2008

Similar Publications