Rate of change in early Huntington's disease: a clinicometric analysis.

Mov Disord 2012 Jan 17;27(1):118-24. Epub 2011 Nov 17.

Department of Neurology, University of Ulm, Ulm, Germany.

Sensitive outcome measures for patients with Huntington's disease (HD) are required for future clinical trials. Longitudinal data were collected from a 3-year study of 379 patients suffering from early HD who were not treated by antipsychotics. Progression of UHDRS item scores was evaluated by linear regression and slope, whereas correlation coefficient, standard error, and P values were estimated on the basis of the data of eight evaluations from screening to study end (36 months). For the functional assessment dimension, the proportion of "no" responses at baseline and at study end was determined. Linear progression was observed for the motor score and for all three functional measures (i.e., functional assessment score, independence assessment score, and total functional capacity score). In contrast, there was little evidence for progression of the behavioral assessment score over the study period, whereas the cognitive assessment score was intermediate. Twenty-two motor-score items showed linear progression, with a slope of >0.003. These included all chorea items, finger tapping and pronation/supination (left and right), gait, tongue protrusion, and tandem walking. Different symptom domains and individual items evolved at different rates in this group of patients suffering from early HD. It may be possible to select sensitive items to create a simplified version of the UHDRS, which would be more efficient and more sensitive for the assessment of disease progression in clinical trials and natural history studies.

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.23847DOI Listing
January 2012
7 Reads

Publication Analysis

Top Keywords

assessment score
16
clinical trials
8
huntington's disease
8
functional assessment
8
suffering early
8
linear progression
8
patients suffering
8
assessment
6
score
6
progression
5
study determined
4
determined linear
4
individual items
4
progression observed
4
observed motor
4
three functional
4
functional measures
4
score three
4
motor score
4
baseline study
4

Similar Publications