GRK2 levels in umbilical arteries of pregnancies complicated by gestational hypertension and preeclampsia.

Authors:
Raffaele Napolitano
Raffaele Napolitano
St George's University of London
Alfonso Campanile
Alfonso Campanile
Ospedale Maggiore Policlinico
Laura Sarno
Laura Sarno
University Federico II
Italy
Antonio Anastasio
Antonio Anastasio
Department of Clinical Medicine
Italy
Giuseppe M Maruotti
Giuseppe M Maruotti
"Federico II" University Hospital
Maddalena Morlando
Maddalena Morlando
University Federico II
Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Pasquale Martinelli
Pasquale Martinelli
University of Naples Federico II

Am J Hypertens 2012 Mar;25(3):366-71

Department of Obstetrics and Gynecology, Prenatal Diagnosis and High Risk Pregnancy Unit, University of Naples, Federico II, Naples, Italy.

Background: G-Protein coupled receptor kinase 2 (GRK2) represents a regulator of cell function in different cardiovascular conditions, including high blood pressure. The relationship between elevated GRK2 levels and impaired vasorelaxant responses is causative of hypertension through the increase in vascular resistances. The aim of this study is to ascertain if this feature is present in the fetal placental vasculature of pregnancies complicated by hypertensive disorders.

Methods: We have assessed GRK2 levels in the umbilical arteries (UA) of 21 preeclamptic or gestational hypertensive and 23 normotensive women at time of delivery.

Results: GRK2 levels were increased in the hypertensive group (0.83 ± 0.14 vs. 0.48 ± 0.06 densitometry units; P < 0.05). GRK2 levels were in correlation and in linear regression with systolic, diastolic, and mean arterial pressure (P < 0.05, r(2) = 0.12, r(2) = 0.11, r(2) = 0.12). Correlations did not reach a significant value for other clinical parameters such as gestational age at birth, umbilical artery pulsatility index, maternal proteinuria, and neonatal birth weight. Out of the 21 hypertensive women, 7 who developed a preeclampsia associated with early preterm delivery (before 34 weeks) had a significantly lower GRK2 levels compared to the remaining 14 (0.51 ± 0.12 vs. 1.08 ± 0.20 densitometry units, P < 0.05).

Conclusions: We conclude that elevated GRK2 levels in the umbilical vasculature is correlated to elevated blood pressure levels, with a likely compensatory rather than causative role since the lack of protective effect of elevated GRK2 levels may negatively affect the outcome of the hypertensive state.

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http://dx.doi.org/10.1038/ajh.2011.211DOI Listing
March 2012
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References

(Supplied by CrossRef)
Article in American journal of obstetrics and gynecology
American journal of obstetrics and gynecology 2000
Article in New England Journal of Medicine
New England Journal of Medicine 2004
Article in Lancet
Sibai et al.
Lancet 2005
Article in European journal of obstetrics, gynecology, and reproductive biology
Bolte et al.
European journal of obstetrics, gynecology, and reproductive biology 2001
Article in Trends in cardiovascular medicine
Carty et al.
Trends in cardiovascular medicine 2008
Article in American Journal of Hypertension
American Journal of Hypertension 2011
Article in American Journal of Hypertension
American Journal of Hypertension 2009

Campanile et al.
2009
Article in Journal of Clinical Investigation
Gros et al.
Journal of Clinical Investigation 1997
Article in Molecular Pharmacology
Eckhart et al.
Molecular Pharmacology 2002
Article in Nature medicine
Liu et al.
Nature medicine 2005

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