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Biochem Biophys Res Commun 2021 Apr 14;557:174-179. Epub 2021 Apr 14.

Division of Applied Pharmacology, Department of Health Promotion, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Japan. Electronic address:

Involvement of the bone matrix protein osteocalcin (OC) in the development of learning and memory, and the prevention of anxiety-like behaviors in mice. However, the direct effects of OC on neurons are still unknown comparing to the mechanism how OC affects systemic energy expenditure and glucose homeostasis. In this study, we investigated the effect of OC on proliferation, differentiation, and survival of neurons using the rat pheochromocytoma cell line PC12. Read More

Biosens Bioelectron 2021 Apr 8;184:113227. Epub 2021 Apr 8.

Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:

In this work, a novel self-enhanced photoelectric active material, Na, K-codoped carbon nitride (NaKCN), was synthesized for constructing sensitive photoelectrochemical (PEC) biosensor to detect target miRNA-182-5p. Ingeniously, the NaKCN displayed glucose oxidase (GOx)-mimicking photocatalytic property, which catalyzed glucose to in situ generate high levels of HO as its own electron donor for enhancing photocurrent. Moreover, the Na, K co-doping could reduce energy gap of carbon nitride material, effectively improving the optical absorptivity and photocatalytic efficiency. Read More

ACS Appl Mater Interfaces 2021 Apr 16. Epub 2021 Apr 16.

Department of Mining-Metallurgy Engineering and Materials Science, POLYMAT, Faculty of Engineering in Bilbao, University of the Basque Country (UPV/EHU), Plaza Torres Quevedo 1, 48013 Bilbao, Spain.

Polymer capsules fabricated the layer-by-layer (LbL) approach have emerged as promising biomedical systems for the release of a wide variety of therapeutic agents, owing to their tunable and controllable structure and the possibility to include several functionalities in the polymeric membrane during the fabrication process. However, the limitation of the capsules with a single functionality to overcome the challenges involved in the treatment of complex pathologies denotes the need to develop multifunctional capsules capable of targeting several mediators and/or mechanisms. Oxidative stress is caused by the accumulation of reactive oxygen species [, hydrogen peroxide (HO), hydroxyl radicals (OH), and superoxide anion radicals (O)] in the cellular microenvironment and is a key modulator in the pathology of a broad range of inflammatory diseases. Read More

BMC Plant Biol 2021 Apr 15;21(1):180. Epub 2021 Apr 15.

Institute of Horticulture, Zhejiang Academy of Agriculture Science, Hangzhou, 310021, Zhejiang, China.

Background: Melatonin, a multifunctional signal molecule, has been reported to play crucial roles in growth and development and stress responses in various plant species. Okra (Abelmoschus esculentus L.) is a food crop with extremely high values of nutrition and healthcare. Read More

J Hazard Mater 2021 Jun 13;411:125137. Epub 2021 Jan 13.

College of Environment, Zhejiang University of Technology, Hangzhou 310032, PR China; Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, PR China. Electronic address:

S-metolachlor (S-ME) is a common chloroacetanilide herbicide. Here, we investigated the effects of S-ME on wheat seedling growth and explored via metabolomics the driver through which S-ME changes the rhizosphere microbiome. The results indicated that 4 mg/kg S-ME had a strong inhibitory effect on plant growth by inducing hydrogen peroxide (HO) levels. Read More