Chronotype predicts activity patterns in the neural underpinnings of the motor system during the day.

Chronobiol Int 2011 Dec;28(10):883-9

Institute of Medical Psychology, Ludwig Maximilian University Munich, Goethestrasse 31/1, Munich, Germany.

Neuroimaging is increasingly used to study the motor system in vivo. Despite many reports of time-of-day influences on motor function at the behavioral level, little is known about these influences on neural motor networks and their activations recorded in neuroimaging. Using functional magnetic resonance imaging (fMRI), the authors studied 15 healthy subjects (9 females; mean ± SD age: 23 ± 3 yrs) performing a self-paced finger-tapping task at different times of day (morning, midday, afternoon, and evening). Blood-oxygenation-level-dependent signal showed systematic differences across the day in task-related motor areas of the brain, specifically in the supplementary motor area, parietal cortex, and rolandic operculum (p(corr)< .0125). The authors found that these time-of-day-dependent hemodynamic modulations are associated with chronotype and not with homeostatic sleep pressure. These results show that consideration of time-of-day for the analysis of fMRI studies is imperative.

Download full-text PDF

Source
http://dx.doi.org/10.3109/07420528.2011.619084DOI Listing
December 2011
5 Reads

Publication Analysis

Top Keywords

motor system
8
motor
6
afternoon evening
4
midday afternoon
4
morning midday
4
times day
4
day morning
4
evening blood-oxygenation-level-dependent
4
blood-oxygenation-level-dependent signal
4
day task-related
4
task-related motor
4
differences day
4
systematic differences
4
signal systematic
4
task times
4
finger-tapping task
4
studied healthy
4
healthy subjects
4
authors studied
4
fmri authors
4

References

(Supplied by CrossRef)

Achermann P et al.
Front. Biosci. 2003

Alexander GE et al.
Trends Neurosci. 1990

Borbely A et al.
Hum. Neurobiol. 1982

Bortz J et al.
2004

Box EP et al.
1970

Brett M et al.
Nat. Rev. Neurosci. 2002

Brown EN et al.
J. Biol. Rhythms 1992

Brown E et al.
Am. J. Physiol. 1997

Buysse DJ et al.
Sleep 2004

Cagnacci A et al.
J. Clin. Endocrinol. Metab. 1992

Cajochen C et al.
Behav. Brain Res. 2004

Similar Publications