Accid Anal Prev 2012 Jan 21;44(1):63-73. Epub 2010 Dec 21.
Ran Naor Road Safety Research Center, Technion - Israel Institute of Technology, Technion City, Haifa 32000, Israel.
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Cardiovasc Diabetol 2018 Jul 26;17(1):106. Epub 2018 Jul 26.
Department of Biological Chemistry, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Background: Sodium glucose co-transporter2 inhibitors reduce the incidence of cardiovascular events in patients with type 2 diabetes mellitus based on the results of recent cardiovascular outcome studies. Herein, we investigated the effects of long-term treatment with canagliflozin on biochemical and immunohistochemical markers related to atherosclerosis and atherosclerosis development in the aorta of apolipoprotein E knockout (Apo-E) mice.
Methods: At the age of 5 weeks, mice were switched from normal to a high-fat diet. Read More
BMJ Open 2017 01 5;7(1):e013634. Epub 2017 Jan 5.
Division of Infectious Diseases, Department of Internal Medicine 1, DZIF Partner Centre, University Hospital Tuebingen, Tuebingen, Germany.
Introduction: Improving our understanding of outbreaks due to antibiotic-resistant bacteria (ARB) and their control is critical in the current public health scenario. The threat of outbreaks due to ARB requires multifaceted efforts. However, a global overview of epidemiological characteristics of outbreaks due to ARB and effective infection control measures is missing. Read More
Environ Toxicol Pharmacol 2016 Jul 18;45:340-5. Epub 2016 Jun 18.
Department of Toxicology & Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Haft-Bagh Blvd., Kerman 7616911319 , Iran; Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Afzalipour's Hospital, Imam Highway, Kerman University of Medical Sciences, Kerman 7616913911, Iran. Electronic address:
The potential preventive and therapeutic effects of thymoquinone (TQ) and its molecular mechanism were evaluated in paraquat (PQ)-induced pulmonary fibrosis in mice. TQ was administered orally at the doses of 20 and 40mg/kg during the course and after development of fibrosis. Pathological changes, expressions of genes involved in fibrogenesis, hydroxyproline (HP) and oxidative stress parameters were determined in the lung tissues. Read More
J Am Chem Soc 2012 May 1;134(18):7896-901. Epub 2012 May 1.
Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université de Paris Sud 11, CNRS, Bât. 420, 15 rue Georges Clemenceau, 91405 Orsay Cedex, France.
Assembly of paramagnetic Cu(2) complexes with a Schiff base scaffold possessing extended electron delocalization together with a quasi-planar structure onto carbon nanotubes induces a diameter-selective charge transfer from the complex to the nanotubes leading to an interestingly large and tunable ambipolar effect. We used complementary techniques such as electron paramagnetic resonance, absorption spectroscopy, and photoluminescence to ensure the success of the assembly process and the integrity of the complex in the nanohybrid. We carried out density functional theory type calculations to rationalize the experimental results, evidencing the selective enhanced interaction of the metal complexes with one type of nanotube. Read More
J Immunol 1997 Mar;158(5):2390-7
Department of Medicine, University of Illinois at Chicago, 60607, USA.
During engagement of the type I IFN receptor, IRS-1 is phosphorylated on tyrosine and associates with the p85 regulatory subunit of the phosphatidylinositol (PI) 3'-kinase, which is a dual-specificity enzyme possessing both lipid and serine kinase activities. We sought to determine whether treatment of cells with IFN-alpha activates the PI 3'-kinase serine kinase. 32P-labeling experiments and phosphoaminoacid analysis of immunoprecipitated IRS-1 protein demonstrated that, in addition to tyrosine phosphorylation, IFN-alpha induces its phosphorylation on serine residues. Read More