J Diabetes Complications 2011 Nov-Dec;25(6):368-70. Epub 2011 Nov 4.
Department of Biochemistry, Government Medical College, Aurangabad, Maharashtra, India.
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Metabolism 2006 Aug;55(8):1014-21
Department of Internal Medicine, Koshigaya Hospital, Dokkyo Medical University, Koshigaya, Saitama 343-8555, Japan.
Sympathetic activation is associated with metabolic syndrome (MS) and increased risk of cardiovascular disease. The aim of this study was to investigate whether cardiac autonomic activity or sympathovagal balance, as estimated by a 24-hour power spectral analysis of heart rate variation, is associated with serum concentrations of high-sensitivity C-reactive protein (hs-CRP), a sensitive predictor for cardiovascular events, in type 2 diabetic patients with and without MS. We studied 104 type 2 diabetic patients (50 female and 54 male). Read More
N Engl J Med 2000 Mar;342(12):836-43
Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Background: Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events.
Methods: We conducted a prospective, nested case-control study among 28,263 apparently healthy postmenopausal women over a mean follow-up period of three years to assess the risk of cardiovascular events associated with base-line levels of markers of inflammation. The markers included high-sensitivity C-reactive protein (hs-CRP), serum amyloid A, interleukin-6, and soluble intercellular adhesion molecule type 1 (sICAM-1). Read More
Circulation 2007 Mar 19;115(12):1528-36. Epub 2007 Mar 19.
Cardiovascular Division, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA.
Background: Data supporting the prognostic significance of high-sensitivity C-reactive protein (hs-CRP) are derived largely from individuals with no overt coronary artery disease or from patients with acute coronary syndromes. In contrast, the ability of hs-CRP to predict outcomes in patients with stable coronary artery disease and the prognostic significance of the Centers for Disease Control/American Heart Association hs-CRP cut points in such a population remain relatively unexplored.
Methods And Results: We measured hs-CRP in 3771 patients with stable coronary artery disease from the Prevention of Events With Angiotensin-Converting Enzyme Inhibition (PEACE) trial, a randomized placebo-controlled trial of the angiotensin-converting enzyme inhibitor trandolapril. Read More
Med Pregl 2006 Mar-Apr;59(3-4):160-4
Klinicko-bolnicki centar Dr Dragisa Misović-Dedinje, Beograd.
INTRODUCTION High levels of inflammatory markers are associated with an increased risk for development of coronary heart disease (CHD). The aim of this study was to estimate relations between oxidized LDL (oxLDL), C-reactive protein (CRP) and conventional lipid risk factors for CHD in type 2 diabetics without coronary heart disease. MATERIAL AND METHODS Three groups of subjects were included in the study. Read More