Joint association of glycemic load and alcohol intake with type 2 diabetes incidence in women.

Authors:
Rania A Mekary
Rania A Mekary
MCPHS University
Boston | United States
Eric B Rimm
Eric B Rimm
Harvard T.H. Chan School of Public Health
Boston | United States
Edward Giovannucci
Edward Giovannucci
Harvard T.H. Chan School of Public Health
Boston | United States
Meir J Stampfer
Meir J Stampfer
Harvard T.H. Chan School of Public Health
Boston | United States
Walter C Willett
Walter C Willett
Harvard T.H. Chan School of Public Health
Boston | United States
David S Ludwig
David S Ludwig
New Balance Foundation Obesity Prevention Center
United States
Frank B Hu
Frank B Hu
Harvard T.H. Chan School of Public Health
United States

Am J Clin Nutr 2011 Dec 2;94(6):1525-32. Epub 2011 Nov 2.

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.

Background: Little is known about the joint association between glycemic index (GI), glycemic load (GL), and alcohol intake with type 2 diabetes (T2D).

Objective: The objective of this study was to examine whether alcohol intake alters the associations between carbohydrate quality (GI) or quality and quantity (GL) and T2D incidence in women.

Design: Participants from the Nurses' Health Study who were free of T2D, cardiovascular disease, or cancer (n = 81,827) at baseline in 1980 were followed for 26 y. Cumulative averages of GI, GL, total carbohydrates, and alcohol intake were calculated every 2-4 y from validated food-frequency questionnaires. Cox proportional hazard models were used to adjust for covariates.

Results: We documented 6950 cases of T2D during follow-up. After adjustment for lifestyle and dietary factors, the positive association between GL and T2D risk was attenuated in subjects with higher alcohol intakes. RRs that compared the top and bottom quintiles of GL were 1.29 (95% CI: 1.11, 1.49; P-trend < 0.001) in women with alcohol intakes of 0 to <5 g/d, 1.34 (95% CI: 0.93, 1.92; P-trend = 0.05) in women with alcohol intakes of 5 to <15 g/d, and 0.99 (95% CI: 0.60, 1.65; P-trend = 0.82) in women with alcohol intakes ≥15 g/d (P-interaction = 0.02). However, a higher intake of alcohol did not modify the positive association between GI and T2D (P-interaction = 0.76).

Conclusion: Our findings suggest that a higher alcohol intake (≥15 g/d) attenuates the positive association between GL and T2D incidence.

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http://dx.doi.org/10.3945/ajcn.111.023754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252550PMC

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December 2011
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References

(Supplied by CrossRef)
Economic costs of diabetes in the US in 2002
Hogan et al.
Diabetes Care 2003
Glycemic index, glycemic load, and chronic disease risk–a meta-analysis of observational studies
Barclay et al.
Am J Clin Nutr 2008

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