Deep brain stimulation of caudal zona incerta and subthalamic nucleus in patients with Parkinson's disease: effects on voice intensity.

Parkinsons Dis 2011 19;2011:658956. Epub 2011 Oct 19.

Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, Sweden.

Deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson's disease (PD) affects speech inconsistently. Recently, stimulation of the caudal zona incerta (cZi-DBS) has shown superior motor outcomes for PD patients, but effects on speech have not been systematically investigated. The aim of this study was to compare the effects of cZi-DBS and STN-DBS on voice intensity in PD patients. Mean intensity during reading and intensity decay during rapid syllable repetition were measured for STN-DBS and cZi-DBS patients (eight patients per group), before- and 12 months after-surgery on- and off-stimulation. For mean intensity, there were small significant differences on- versus off-stimulation in each group: 74.2 (2.0) dB contra 72.1 (2.2) dB (P = .002) for STN-DBS, and 71.6 (4.1) dB contra 72.8 (3.4) dB (P = .03) for cZi-DBS, with significant interaction (P < .001). Intensity decay showed no significant changes. The subtle differences found for mean intensity suggest that STN-DBS and cZi-DBS may influence voice intensity differently.

Download full-text PDF

Source
http://dx.doi.org/10.4061/2011/658956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199057PMC
November 2011
5 Reads

Publication Analysis

Top Keywords

voice intensity
12
intensity decay
8
subthalamic nucleus
8
parkinson's disease
8
intensity
8
stn-dbs czi-dbs
8
zona incerta
8
patients parkinson's
8
brain stimulation
8
deep brain
8
stimulation caudal
8
caudal zona
8
patients
6
stn-dbs
5
czi-dbs
5
measured stn-dbs
4
czi-dbs interaction
4
czi-dbs stn-dbs
4
patients patients
4
group before-
4

References

(Supplied by CrossRef)

Folia Phoniatrica et Logopaedica 2004

Journal of Speech and Hearing Disorders 1978

Journal of Medical Speech-Language Pathology 2001

American Journal of Speech-Language Pathology 1997

Behavioural Neurology 1998

Neuropsychiatry, Neuropsychology and Behavioral Neurology 2001

Similar Publications