Self-replication of information-bearing nanoscale patterns.

Nature 2011 Oct 12;478(7368):225-8. Epub 2011 Oct 12.

Department of Chemistry, New York University, New York, New York 10003, USA.

DNA molecules provide what is probably the most iconic example of self-replication--the ability of a system to replicate, or make copies of, itself. In living cells the process is mediated by enzymes and occurs autonomously, with the number of replicas increasing exponentially over time without the need for external manipulation. Self-replication has also been implemented with synthetic systems, including RNA enzymes designed to undergo self-sustained exponential amplification. An exciting next step would be to use self-replication in materials fabrication, which requires robust and general systems capable of copying and amplifying functional materials or structures. Here we report a first development in this direction, using DNA tile motifs that can recognize and bind complementary tiles in a pre-programmed fashion. We first design tile motifs so they form a seven-tile seed sequence; then use the seeds to instruct the formation of a first generation of complementary seven-tile daughter sequences; and finally use the daughters to instruct the formation of seven-tile granddaughter sequences that are identical to the initial seed sequences. Considering that DNA is a functional material that can organize itself and other molecules into useful structures, our findings raise the tantalizing prospect that we may one day be able to realize self-replicating materials with various patterns or useful functions.

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature10500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192504PMC
October 2011
25 Reads

Publication Analysis

Top Keywords

tile motifs
8
instruct formation
8
fabrication requires
4
seven-tile granddaughter
4
granddaughter sequences
4
materials fabrication
4
step self-replication
4
self-replication materials
4
requires robust
4
daughters instruct
4
capable copying
4
systems capable
4
formation seven-tile
4
robust general
4
general systems
4
exciting step
4
sequences identical
4
sequences considering
4
enzymes designed
4
rna enzymes
4

References

(Supplied by CrossRef)

TA Lincoln et al.
Science 2009

EA Wintner et al.
Acc. Chem. Res. 1994

R Schulman et al.
Proc. Natl Acad. Sci. USA 2007

C Lin et al.
Proc. Natl Acad. Sci. USA 2008

DH Lee et al.
Nature 1997

NC Seeman et al.
Nature 2003

L Zhu et al.
J. Am. Chem. Soc. 2003

J Zheng et al.
Nano Lett. 2006

D Nykypanchuk et al.
Nature 2008

SY Park et al.
Nature 2008

AJ Kim et al.
Langmuir 2006

Similar Publications