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Acc Chem Res 2021 Apr 7. Epub 2021 Apr 7.

Center of Chemistry for Frontier Technologies, Department of Chemistry, Zhejiang University, Hangzhou 310027, China.

ConspectusTransition-metal-catalyzed C-O bond activation provides a useful strategy for utilizing alcohol- and phenol-derived electrophiles in cross-coupling reactions, which has become a research field of active and growing interest in organic chemistry. The synergy between computation and experiment elucidated the mechanistic model and controlling factors of selectivities in these transformations, leading to advances in innovative C-O bond activation and functionalization methods.Toward the rational design of C-O bond activation, our collaborations with the Jarvo group bridged the mechanistic models of C(sp)-O and C(sp)-O bond activations. Read More

Beilstein J Nanotechnol 2021 17;12:257-269. Epub 2021 Mar 17.

Department of Chemistry and Centre for Materials Science and Nanotechnology (SMN), Faculty of Mathematics and Natural Sciences, University of Oslo, P.O. Box 1126 Blindern, NO-0318 Oslo, Norway.

Seven gold(I) N-heterocyclic carbene (NHC) complexes were synthesized, characterized, and identified as suitable precursors for focused electron beam-induced deposition (FEBID). Several variations on the core Au(NHC)X moiety were introduced, that is, variations of the NHC ring (imidazole or triazole), of the alkyl N-substituents (Me, Et, or iPr), and of the ancillary ligand X (Cl, Br, I, or CF). The seven complexes were tested as FEBID precursors in an on-substrate custom setup. Read More

Chemistry 2021 Apr 6. Epub 2021 Apr 6.

Oulun Yliopisto, Molecular Sciences Institute, School of Chemistry, Laboratory of Inorganic Chemistry, Environmental and Chemical Engineering, University of Oulu, PO Box 3000, 90014, Oulu, FINLAND.

The syntheses of bis(triazolium)carbazole precursors and their corresponding coinage metal (Au, Ag) complexes are reported. For alkylated triazolium salts, di- or tetranuclear complexes with bridging ligands were isolated, while the bis(aryl) analogue afforded a bis(carbene) Au I -CNC pincer complex suitable for oxidation to the redox-stable [Au III (CNC)Cl] + cation. Although the ligand salt and the [Au III (CNC)Cl] + complex were both notably cytotoxic toward the breast cancer cell line MDA-MB-231, the Au III complex was somewhat more selective. Read More