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J Am Soc Mass Spectrom 2021 Mar 3. Epub 2021 Mar 3.

Department of Chemistry, University of Washington, Bagley Hall, Box 351700, Seattle, Washington 98195-1700, United States.

Diazirine-tagged d- and l-adrenaline derivatives formed abundant noncovalent gas-phase ion complexes with peptides -Ac-SSIVSFY-NH (peptide S) and -Ac-VYILLNWIGY-NH (peptide V) upon electrospray ionization. These peptide sequences represent the binding motifs in the β-adrenoreceptor. The structures of the gas-phase complexes were investigated by selective laser photodissociation of the diazirine chromophore at 354 nm, which resulted in a loss of N and formation of a transient carbene intermediate in the adrenaline ligand without causing its expulsion. Read More

Inorg Chem 2021 Feb 25. Epub 2021 Feb 25.

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.

The conjugate acids of 1,2,3-triazolylidene mesoionic carbenes can be prepared in a straightforward fashion by alkylation of 1-substituted 1,2,3-triazoles. However, this becomes a much more challenging proposition when other nucleophilic centers are present, which has curtailed the development of ligands containing multiple 1,2,3-triazolylidene donors. Herein, methylation of a series of tris[(1-aryl-1,2,3-triazol-4-yl)methyl]amines possessing both electron-rich and electron-deficient aromatic substituents, using MeOBF, is shown to proceed with much higher chemoselectivity under mechanochemical conditions than when conducted in solution. Read More

Acc Chem Res 2021 Feb 22. Epub 2021 Feb 22.

Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche (ISOF-CNR), Via P. Gobetti 101, 40129 Bologna, Italy.

ConspectusIridium(III) complexes have assumed a prominent role in the areas of photochemistry and photophysics due to the peculiar properties of both the metal itself and the ligand environment that can be assembled around it. Ir(III) is larger, heavier, and bears a higher ionic charge than its analogue and widely used d ions such as Fe(II) and Ru(II). Accordingly, its complexes exhibit wider ligand-field d-d orbital splitting with electronic levels centered on the metal, typically nonemissive and photodissociative, not playing a relevant role in excited-state deactivations. Read More

J Inorg Biochem 2021 Jan 20;217:111355. Epub 2021 Jan 20.

Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy. Electronic address:

Metal complexes of N-heterocyclic carbene (NHC) ligands are the object of increasing attention for therapeutic purposes. Among the different metal centres, interest on Au-based compounds started with the application as anti-arthritis drugs. On the other hand, Ag(I) antimicrobial properties have been known for a long time. Read More

Metallomics 2021 Feb;13(2)

School of Chemistry, University College Dublin, Belfield, Stillorgan, Dublin 4, Republic of Ireland.

N-heterocyclic silver carbene compounds have been extensively studied and shown to be active agents against a host of pathogenic bacteria and fungi. By incorporating hypothesized virulence targeting substituents into NHC-silver systems via salt metathesis, an atom-efficient complexation process can be used to develop new complexes to target the passive and active systems of a microbial cell. The incorporation of fatty acids and an FtsZ inhibitor have been achieved, and creation of both the intermediate salt and subsequent silver complex has been streamlined into a continuous flow process. Read More