A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs.

Authors:
Dr. Min-Dian Li, PhD
Dr. Min-Dian Li, PhD
Harvard TH Chan School of Public Health
Postdoctoral Fellow
Cellular and Molecular Physiology
Boston, MA | United States
Xiaoyong Yang
Xiaoyong Yang
Yale University School of Medicine
New Haven | United States

PPAR Res 2011 15;2011:742785. Epub 2011 Sep 15.

Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USA.

Members of the nuclear receptor superfamily have vital roles in regulating immunity and inflammation. The founding member, glucocorticoid receptor (GR), is the prototype to demonstrate immunomodulation via transrepression of the AP-1 and NF-κB signaling pathways. Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of inflammation. This review examines the history and current advances in nuclear receptor regulation of inflammation by the crosstalk with AP-1 and NF-κB signaling, focusing on the roles of GR and PPARs. A better understanding of the molecular mechanism by which nuclear receptors inhibit proinflammatory signaling pathways will enable novel therapies to treat chronic inflammation.

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http://dx.doi.org/10.1155/2011/742785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175381PMC

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November 2011
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References

(Supplied by CrossRef)
Article in Science
Science 1988
Article in Journal of the Royal Society of Medicine
Journal of the Royal Society of Medicine 1998
Article in Annual review of genetics
Annual review of genetics 1985
Article in Nuclear Receptor Signaling
Nuclear Receptor Signaling 2008

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