J Psychopharmacol 2012 May 22;26(5):603-17. Epub 2011 Sep 22.
Department of Psychiatry, General Hospital Sint-Jan Brugge-Oostende AV, Brugge, Belgium.
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J Clin Psychiatry 2006 Apr;67(4):509-16
Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Background: Randomized, controlled trials have demonstrated efficacy for atypical antipsychotics in the treatment of mania in bipolar disorder, either as monotherapy or adjunctive treatment. However, there are no published comparisons of individual atypical antipsychotics for mania.
Data Sources And Study Selection: We conducted a systematic review and meta-analysis of randomized, placebo-controlled monotherapy and adjunctive therapy trials of atypical antipsychotics for acute bipolar mania. Read More
Int J Neuropsychopharmacol 2010 Feb 29;13(1):5-14. Epub 2009 Jul 29.
Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Randomized, controlled trials have demonstrated efficacy for second-generation antipsychotics in the treatment of acute mania in bipolar disorder. Despite depression being considered the hallmark of bipolar disorder, there are no published systematic reviews or meta-analyses to evaluate the efficacy of modern atypical antipsychotics in bipolar depression. We systematically reviewed published or registered randomized, double-blind, placebo-controlled trials (RCTs) of modern antipsychotics in adult bipolar I and/or II depressive patients (DSM-IV criteria). Read More
Clin Ther 2011 Nov 4;33(11):1643-58. Epub 2011 Nov 4.
University of Florida and Florida Clinical Research Center, LLC, Maitland, Florida.
Background: Bipolar disorder, a highly recurrent and chronic condition, often necessitates periods of hospitalization and requires lifelong treatment with medication. It is characterized by alternating episodes of mania and depression. Given the severity of mania, physicians must be able to control symptoms rapidly. Read More
Arch Gen Psychiatry 2007 Apr;64(4):442-55
Department of Psychiatry and Psychotherapy, Georg-August University Goettingen, Goettingen, Germany.
Context: Recommendations of treatment guidelines concerning the use of second-generation antipsychotic (SGA) agents for acute mania vary substantially across committees or working groups. Meta-analyses addressing the use of SGAs in the treatment of acute mania are lacking.
Objective: To conduct a meta-analysis of the efficacy and safety of SGAs in the treatment of acute mania. Read More