Effect of proton pump inhibitor (PPI) treatment in obstructive sleep apnea syndrome: an esophageal impedance-pHmetry study.

Hepatogastroenterology 2011 Sep-Oct;58(110-111):1566-73. Epub 2011 Jul 15.

Department of Gastroenterology, Istanbul University, Istanbul, Turkey.

Background/aims: There is an increasing interest for a link between gastroesophageal reflux (GER) and obstructive sleep apnea syndrome (OSAS). There is no study in the literature which examines the relationship between OSAS and esophageal functions in adults with impedance. We first evaluated the role of reflux in OSAS with simultaneous polysomnography and impedance-pHmetry and then investigated whether the effect of proton pump inhibitor (PPI) treatment changes in these parameters.

Methodology: Twenty two OSAS patients who had applied to sleep laboratory between September 2007 and May 2008 were consecutively enrolled to the study. Twenty four hours esophageal impedance study was performed during polysomnographic recording. At least 50% of all apneas in patients must proceed with a reflux event in 2 minute intervals in order to be considered reflux related apnea patient.

Results: Pathologic reflux episodes were determined in 20 patients (8 were weakly acidic, 12 were acidic). Reflux dependent apnea was found in 6 patients. There was endoscopically esophagitis in all reflux related apnea patients. There was a negative correlation between initial mean SaO2 and gas reflux events at night (p=0.004, r =-0.588) and mixed reflux events at night (p=0.02, r=0.493). There was a statistically significant regression of AHI (apnea hypopnea index) after 3-months PPI treatment (p=0.012).

Conclusions: Reflux may trigger apnea in some of the OSAS patients. Therefore, each OSAS patient must be inquired about esophageal and extraesophageal symptoms of reflux.

Download full-text PDF

Source
http://dx.doi.org/10.5754/hge10465DOI Listing
January 2012
7 Reads

Publication Analysis

Top Keywords

ppi treatment
12
reflux
11
obstructive sleep
8
sleep apnea
8
reflux events
8
osas patients
8
apnea syndrome
8
events night
8
reflux apnea
8
proton pump
8
apnea patients
8
pump inhibitor
8
inhibitor ppi
8
apnea
7
patients
6
osas
6
apnea patientresults
4
order considered
4
patientresults pathologic
4
considered reflux
4

Similar Publications